Muscle loss undermines your success

The weight you lose on GLP medications might come back with a vengeance if you're not careful about how you lose it. "If you're just starving yourself, you're gonna be losing your lean body mass and you're gonna gain the weight back and maybe even more," Dr. McCann cautions in her post. The reason is simple but often overlooked – muscle burns calories continuously throughout the day, and when you lose muscle instead of fat, your metabolism slows down. This metabolic downshift makes maintaining weight loss nearly impossible for many patients, according to Dr. McCann.

Protein intake becomes critical

When appetite suppression kicks in, many patients struggle with getting adequate nutrition. Dr. McCann emphasizes that protein should be your top priority. "If you don't feel like eating on these medications, then you need to make sure you at least take in two things during the day," she advises. Those two non-negotiables are protein and water. Your muscles need protein to maintain their mass during weight loss, and without adequate intake, your body will break down muscle tissue for energy – exactly what you don't want during weight management.

Quality matters for protein sources

Not all protein sources provide the same benefits during GLP-1 treatment. "I have always, for over a decade, recommended this Cornerstone meal replacement," says Dr. McCann. She explains that high-quality protein supplements with added vitamins and minerals can help ensure you're getting essential nutrients even when your appetite is significantly reduced. Two protein-rich meal replacements daily can provide the foundation your body needs while the medication works to control hunger and blood sugar levels.

Exercise preserves muscle function

The second pillar of successful weight management on GLP medications is regular physical activity. "Resistance training is great. It helps build your muscle," Dr. McCann notes. You don't need to become a gym enthusiast overnight – even modest amounts of exercise make a difference. Dr. McCann suggests starting with just 15-20 minutes of activity and gradually increasing duration and intensity. This approach helps preserve muscle mass while the medication helps control appetite.

Compound medications are disappearing

If you've been using compounded versions of GLP medications, significant changes are coming. "The compounded GLPs are gone," Dr. McCann states. She explains that tirzepatide (the active ingredient in Zepbound and Mounjaro) has been removed from the FDA shortage list, meaning compounding pharmacies can no longer legally produce it. Semaglutide (found in Ozempic and Wegovy) compounds will soon follow the same path, leaving many patients wondering about their options.

Manufacturer price drops offer relief

Despite the end of compounded options, there's encouraging news for patients. "Don't panic. The companies have actually lowered their cash price, and this is great news for patients," Dr. McCann reassures. Brand-name manufacturers have introduced more affordable options in response to market demands and increased production capacity. These price reductions make the FDA-approved versions more accessible to patients who were previously relying on compounded alternatives.

Tirzepatide becomes more affordable

For patients preferring tirzepatide (Zepbound/Mounjaro), Eli Lilly has created a more budget-friendly option. "Instead of having it in the auto-injectors, they are sending it in vials, just like the compounded pharmacies did," Dr. McCann explains in another post. This shift in delivery method allows for significant cost savings. According to Dr. McCann, patients can now get the 10mg dose for approximately $500 per month compared to $1,200-$1,500 for the auto-injector version when paying cash.

How to access discounted medications

Getting the discounted version requires specific steps. "Any prescriber should be able to send this from their EHR. They just have to look for the Eli Lilly pharmacy in their e-prescribe," says Dr. McCann. She notes that the 5mg, 7.5mg, and 10mg doses are all available at the $500 cash price. There's also an option for patients with insurance that doesn't cover the medication, priced around $650. These vials require self-injection rather than using the auto-injector device.

Special handling requirements

These medications require proper storage to maintain effectiveness. "You do have a shipping cost in there. It does have to be shipped on ice because it needs to be refrigerated," Dr. McCann points out. This refrigeration requirement is standard for all GLP-1 medications, whether in vial or auto-injector form. The shipping costs add a small premium to the base price but still represent significant savings compared to previous options.

The bottom line on GLP success

Success with GLP medications requires a comprehensive approach. "Protein, exercise, keep your muscle so you at least have a chance of keeping the weight off," summarizes Dr. McCann. While the medications provide powerful appetite control and metabolic benefits, they work best as part of a complete strategy. By focusing on preserving muscle mass through adequate protein intake and regular exercise, patients maximize their chances of maintaining weight loss long-term, even as medication options and pricing continue to evolve. And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.

The Pre-Medication Mindset

  

 

 

 

 

 

 

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A post shared by Stephanie Snow | Weight Loss Provider (@stephsnow_np)

Even healthcare providers get nervous about starting new treatments. "Yep. Even as a nurse practitioner, I was nervous to start a GLP-1," Stephanie admits in her post. She worried about the side effects, giving herself injections, and whether this would just be another temporary solution. Stephanie explains that her biggest concern wasn't just losing weight—it was creating sustainable change in her life.

Making a Commitment Beyond the Medication

  

 

 

 

 

 

 

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A post shared by Stephanie Snow | Weight Loss Provider (@stephsnow_np)

When starting her GLP-1 journey, Stephanie made a crucial decision: "If I was going to use this tool, I was going to do the work alongside it," she shares. This meant learning proper nutrition beyond just eating less, beginning strength training despite initial discomfort, and maintaining consistency even when progress slowed. Stephanie emphasizes that success with GLP-1s isn't about perfection—it's about commitment to the process.

The Surprising Fullness Factor

One of the most unexpected aspects of GLP-1 medications is how they affect your appetite. "One of the biggest surprises of GLP-1s is how quickly you'll feel full. It's almost like your body hits a 'stop' button," says Stephanie. This dramatic change in hunger cues requires an adjustment period. Stephanie suggests trusting your body's new signals and learning to recognize when you're genuinely satisfied—which often happens much sooner than you'd expect.

Hydration Is Non-Negotiable

Water becomes exceptionally important when taking GLP-1 medications. "Staying hydrated is crucial on GLP-1s," Stephanie advises. Proper hydration helps manage common side effects like nausea and supports digestion as your body adapts to eating smaller portions. Stephanie recommends carrying water everywhere and making consistent hydration a top priority throughout your day.

Protein: Your Body's Best Support

As your caloric intake decreases, the quality of what you eat becomes even more critical. "Protein is your new best friend," Stephanie explains. High-protein meals and snacks help maintain energy levels, preserve muscle mass during weight loss, and create lasting feelings of fullness between meals. Stephanie suggests focusing on incorporating protein into every meal to support your body during this transition.

Embracing Imperfect Progress

The weight loss journey with GLP-1s isn't always smooth. "Some days you'll feel amazing, and other days might feel like a struggle. That's completely normal," Stephanie reassures. Progress rarely follows a perfect linear path, and acknowledging this reality helps build resilience. Stephanie encourages patients to practice self-compassion during challenging days rather than viewing setbacks as failures.

The Power of Patience

While GLP-1 medications have shown impressive results for many users, they're not an overnight solution. "GLP-1s work, but they're not magic!" Stephanie emphasizes. Sustainable weight loss requires time, consistency, and realistic expectations. Stephanie reminds us that the most successful outcomes come from viewing these medications as tools within a broader lifestyle change rather than quick fixes.

Finding Your Support System

Starting a GLP-1 medication can feel overwhelming, especially when managing side effects or adjusting to new eating patterns. "If you're feeling nervous too, I see you. Even the pros get nervous. You're not alone," says Stephanie. She highlights the importance of finding healthcare providers who understand GLP-1 medications and connecting with others on similar journeys for emotional support and practical advice. And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.