FDA Alert: Ozempic Overdose Risks and Weight Loss Drug Safety

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        FDA Alert: Risks of Injectable Weight-Loss Drug Overdose
    Taking more Ozempic than prescribed can land you in the hospital, they warn. 
By Leah GrothAug 02, 2024
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Leah Groth has decades of experience covering all things health, wellness and fitness related. 
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By Leah GrothAug 02, 2024
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When it comes to drugs, following the recommended or prescribed dosages is crucial. While it can be tempting to take more than prescribed, it can be hazardous to your health. This week, the FDA issued an alert about Ozempic and other weight loss drugs, revealing there have been several reports of overdoses. However, instead of helping people lose more weight, taking more than recommended is resulting in some pretty serious side effects.
The FDA Has Received Several Reports of Ozempic Overdose
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In a press release, the FDA revealed that they have received reports of “adverse events, some requiring hospitalization, that may be related to overdoses due to dosing errors associated with compounded semaglutide injectable products.”
They maintain that people are doing it incorrectly. “Dosing errors have resulted from patients measuring and self-administering incorrect doses of the drug and health care providers miscalculating doses of the drug,” they continue. “The majority of the reports described patients mistakenly drawing up more than the prescribed dose from a multiple-dose vial during self-administration. In these instances, patients administered five to 20 times more than the intended dose of semaglutide.”
Many of the Patients Were Inexperienced with Self-Injections
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They encourage patients to talk with their healthcare provider or compounder about how to measure and administer the intended dose of compounded semaglutide.
“Many of the patients who received vials of compounded semaglutide lacked experience with self-injections, according to the adverse event reports. Unfamiliarity with withdrawing medication from a vial into a syringe coupled with confusion between different units of measurement (e.g., milliliters, milligrams, and “units”) may have contributed to dosing errors,” they say.
Providers Need to Counsel Patients
Shutterstock
FDA encourages healthcare providers and compounders to provide patients with the appropriate syringe size for the intended dose and counsel patients on how to measure the intended dose using the syringe.
Additionally, health care providers should be vigilant when prescribing and administering compounded semaglutide, as there may be different concentrations available. If uncertain, health care providers should contact the compounder about calculating the correct dose of medication to prescribe or administer.
These Are the Signs of Ozempic Overdose
Shutterstock
According to the prescribing information for FDA-approved semaglutide injection, there are several adverse effects of overdose, including severe nausea, severe vomiting and severe hypoglycemia (low blood sugar levels).
“A prolonged period of observation and treatment for overdose symptoms may be necessary due to the long half-life of semaglutide of about one week,” they add.
RELATED:20 Possible Ozempic Side Effects
Compounded Versions Are Being Marketed for Weight Loss and Are “Riskier”
Shutterstock
The FDA also reveals that there are compounded semaglutide products marketed for weight loss, which are riskier than the pure versions. “Compounded drugs pose a higher risk to patients than FDA-approved drugs because compounded drugs do not undergo FDA premarket review for safety, quality or effectiveness. Compounded drugs should only be used for patients whose medical needs cannot be met by an available FDA-approved drug,” they say.
Amongst the reports, the FDA reveals that some side effects were serious. “Some patients sought medical attention or required hospitalization. Adverse events included gastrointestinal effects (e.g., nausea, vomiting, abdominal pain), fainting, headache, migraine, dehydration, acute pancreatitis, and gallstones,” they say. If you read this article, don't miss these 20 Things You Need to Know About Ozempic and Weight Loss.
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Nutrition & Diet
        FDA Alert: Risks of Injectable Weight-Loss Drug Overdose
    

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By Leah GrothAug 02, 2024
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Leah Groth has decades of experience covering all things health, wellness and fitness related. 
 See Full Bio 
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   FACT CHECKED BY
   Christopher Roback
✓Fact-Checked
Our content is fact checked by our senior editorial staff to reflect accuracy and ensure our readers get
			   sound information and advice to make the smartest, healthiest choices.
We adhere to structured guidelines for sourcing information and linking to other resources, including
               scientific studies and medical journals.
If you have any concerns about the accuracy of our content, please reach out to our editors by e-mailing
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When it comes to drugs, following the recommended or prescribed dosages is crucial. While it can be tempting to take more than prescribed, it can be hazardous to your health. This week, the FDA issued an alert about Ozempic and other weight loss drugs, revealing there have been several reports of overdoses. However, instead of helping people lose more weight, taking more than recommended is resulting in some pretty serious side effects.
The FDA Has Received Several Reports of Ozempic Overdose
Shutterstock
In a press release, the FDA revealed that they have received reports of “adverse events, some requiring hospitalization, that may be related to overdoses due to dosing errors associated with compounded semaglutide injectable products.”
They maintain that people are doing it incorrectly. “Dosing errors have resulted from patients measuring and self-administering incorrect doses of the drug and health care providers miscalculating doses of the drug,” they continue. “The majority of the reports described patients mistakenly drawing up more than the prescribed dose from a multiple-dose vial during self-administration. In these instances, patients administered five to 20 times more than the intended dose of semaglutide.”
Many of the Patients Were Inexperienced with Self-Injections
Shutterstock
They encourage patients to talk with their healthcare provider or compounder about how to measure and administer the intended dose of compounded semaglutide.
“Many of the patients who received vials of compounded semaglutide lacked experience with self-injections, according to the adverse event reports. Unfamiliarity with withdrawing medication from a vial into a syringe coupled with confusion between different units of measurement (e.g., milliliters, milligrams, and “units”) may have contributed to dosing errors,” they say.
Providers Need to Counsel Patients
Shutterstock
FDA encourages healthcare providers and compounders to provide patients with the appropriate syringe size for the intended dose and counsel patients on how to measure the intended dose using the syringe.
Additionally, health care providers should be vigilant when prescribing and administering compounded semaglutide, as there may be different concentrations available. If uncertain, health care providers should contact the compounder about calculating the correct dose of medication to prescribe or administer.
These Are the Signs of Ozempic Overdose
Shutterstock
According to the prescribing information for FDA-approved semaglutide injection, there are several adverse effects of overdose, including severe nausea, severe vomiting and severe hypoglycemia (low blood sugar levels).
“A prolonged period of observation and treatment for overdose symptoms may be necessary due to the long half-life of semaglutide of about one week,” they add.
RELATED:20 Possible Ozempic Side Effects
Compounded Versions Are Being Marketed for Weight Loss and Are “Riskier”
Shutterstock
The FDA also reveals that there are compounded semaglutide products marketed for weight loss, which are riskier than the pure versions. “Compounded drugs pose a higher risk to patients than FDA-approved drugs because compounded drugs do not undergo FDA premarket review for safety, quality or effectiveness. Compounded drugs should only be used for patients whose medical needs cannot be met by an available FDA-approved drug,” they say.
Amongst the reports, the FDA reveals that some side effects were serious. “Some patients sought medical attention or required hospitalization. Adverse events included gastrointestinal effects (e.g., nausea, vomiting, abdominal pain), fainting, headache, migraine, dehydration, acute pancreatitis, and gallstones,” they say. If you read this article, don't miss these 20 Things You Need to Know About Ozempic and Weight Loss.

        
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        3 New Ozempic and Wegovy Side Effects
    

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By Ferozan MastAug 19, 2024
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Ferozan Mast is a science, health and wellness writer with a passion for making science and research-backed information accessible to a general audience. 
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With 1 in 8 US adults having tried a GLP-1 drug like Ozempic or Mounjaro at some point and half of those currently using a prescription, approximately 15 million people are taking these drugs, according to a survey by KFF. With the popularity of these medications exploding, tracking side effects is more important than ever. New research published in JAMA shows that non-diabetics who take the drugs could experience serious and unpleasant side effects. Here’s what those side effects are, plus others to expect from taking a GLP-1 drug.
PancreatitisShutterstock
Non-diabetic users have a roughly nine times higher chance of developing pancreatitis. “It's definitely important that we're talking about this, but I want to keep it in perspective,” Dr. Tara Narula tells TODAY. “These drugs have been around and treating diabetic patients for over ten years, and we've really known about a lot of these side effects, bowel obstruction, pancreatitis, in fact, many of them are on the labels for these drugs.”
Bowel ObstructionNon-diabetic users have a four times higher risk of a bowel obstruction. “But the absolute risks are small, so these are rare,” Dr. Narula says. “We're talking about, for example, gastroparesis, which is this concept of slowing stomach emptying. We're talking about going from 0.3% with these non-GLP drugs to 1% with Ozempic, 0.3% to 0.8 or 0.7% with the other drugs. So these are small increases.”
RELATED:What Happens to Your Body When You Stop Taking Ozempic
Stomach ParalysisShutterstock
Non-diabetic users have a more than three-and-a-half times higher risk of stomach paralysis. “That's actually how this drug partially works, which is slowing the emptying of the stomach,” Dr. Narula says. “So it helps you feel fuller longer. The problem is, in some people, if it is severe, you will end up with nausea, vomiting, abdominal pain, feeling full bloating. So it's important we're raising awareness, but we want to keep it in perspective.”
No Off-Label DrugsShutterstock
Dr. Narula makes it clear no one should be trying to get these drugs without going through a medical professional. “People should not be getting this drug off the internet,” she says. “They should not be getting it without sitting down with a healthcare provider who can really talk to you about the risks and the benefits. Are you someone, for example, who has a history of bowel problems or pancreatitis? Then you probably shouldn't be taking this drug. Do the benefits outweigh? And yes, for obesity, we're talking about cardiovascular risks, cancer risks.”
Take It SlowShutterstock
Dr. Narula recommends starting on a low dose and increasing if necessary. “For a lot of people, there is going to be a benefit here, but you really want to do it the right way in terms of starting these drugs. Start low; you don't increase it until four to six weeks. You monitor for side effects, and if you need to, you can lower the dose. This healthcare provider should be talking to you about non-GI risks as well.”
There Are Benefits TooShutterstock
Dr. Narula says 40 to 60% of my patients are talking about GLP-1 drugs. “I mean, so many of my patients struggle with obesity, and many of them want to know about other options besides bariatric surgery and meeting with a nutritionist,” she says. “They say I've tried everything, and I can't figure out a way to lose weight. And we know that with these medications, we are seeing benefits in a cardiovascular high-risk population for lowering the risk of heart attack and stroke. So there are benefits for those people. So it is important to talk to your doctor about it. It's not for everyone. It may be for you, but really have that conversation.”
RELATED: 20 Things You Need to Know About Ozempic and Weight Loss
Vision IssuesShutterstock
Ozempic and Wegovy may also cause several other side effects, like vision issues. “It may seem strange that a drug made to help control diabetes could make your eyesight worse, but it’s something we’ve known about for a while,” says Raj K Maturi, MD. “A large clinical study suggested that there is an association between blood sugar control and worsening of diabetic retinopathy.”
HypoglycemiaShutterstock
Ozempic may cause hypoglycemia in some people. “Signs and symptoms of low blood sugar may include dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery” Ozempic makers warn.
Gallbladder IssuesShutterstock
Some people taking GLP-1 drugs may experience gallbladder issues. “Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes,” according to research published in the Journal of the American Medical Association.
Thyroid CancerShutterstock
Ozempic may cause thyroid cancer, but a study shows no significant risk. “Our study covers a broad group of patients and provides strong support that GLP-1 analogs are not associated with an increased risk of thyroid cancer,” Björn Pasternak, principal researcher at the Department of Medicine at Karolinska Institutet, said in a statement.
RELATED:20 Possible Ozempic Side Effects
Ozempic FaceShutterstock
Fast weight loss may lead to a more hollowed-out look to the face, hence the term ‘Ozempic Face’. “The term is misleading because this can be a side effect of any GLP-1 drug or any other cause of rapid weight loss,” Lisa Catanese, ELS, says via Harvard Health. “If weight is lost in a more gradual way, these changes may not be as noticeable. It's the faster pace of weight loss that occurs with GLP-1 drugs that can make facial changes more obvious.”
GI IssuesShutterstock
GLP-1 drugs may cause constipation and diarrhea. “Gradual dosing while on Ozempic is crucial to mitigate the risk of severe constipation associated with higher doses,” Andrew Le, MD, tells Buoy Health. “Constipation caused by Ozempic usually subsides over time, with the median duration of constipation lasting 47 days.”
Fatigue and HeadacheShutterstock
Fatigue and headaches are also common side effects. “Gastrointestinal problems are the most common side effects since Wegovy can slow down people’s digestive systems,” Dr. Cecilia Low Wang, endocrinology, diabetes and metabolism expert, tells UC Health. “During clinical trials, some participants experienced nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, bloating and gas.”
RELATED: I Lost 10 Pounds in 30 Days With Walking and Eating Real Food
Severe Side EffectsShutterstock
Dr. Low Wang says side effects can be so severe some people stop taking the drug. “About one in five people might stop because they are experiencing bad side effects,” she tells UC Health. “I encourage some patients to stay at the lower dose level for a longer period of time to see if they can tolerate it better and still get some benefit from the medication. Or if they don’t tolerate this medication, we might try a different one.” And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.
Nutrition & Diet
        20 Things You Need to Know About Ozempic and Weight Loss
    

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By Leah GrothMay 12, 2024
Leah Groth
Writer, Editor, and Content Creator
Leah Groth has decades of experience covering all things health, wellness and fitness related. 
 See Full Bio 
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   FACT CHECKED BY
   Christopher Roback
✓Fact-Checked
Our content is fact checked by our senior editorial staff to reflect accuracy and ensure our readers get
			   sound information and advice to make the smartest, healthiest choices.
We adhere to structured guidelines for sourcing information and linking to other resources, including
               scientific studies and medical journals.
If you have any concerns about the accuracy of our content, please reach out to our editors by e-mailing
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Are you thinking about using Ozempic or another weight loss drug? Before you schedule an appointment with an MD or telemedicine doctor, educating yourself about the drug will give you a better idea of whether or not it’s worth it. Here is everything you need to know about Ozempic—how it works and its benefits for weight loss, how much it costs, and the potential side effects.
How Ozempic Works
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How exactly do weight loss drugs help you lose weight? “Ozempic enhances the release and action of insulin throughout the body, which helps with fat loss,” explains Dr. Sue Decotiis, MD, NYC weight-loss doctor.
Ozempic Shuts Down Your Appetite, and You Feel Full Faster
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“Weight loss drugs also have a tremendous effect on satiety, shutting down appetite so the patient feels very full after eating much less food,” she explains. “Ozempic acts on receptors in the gut and brain that regulate appetite.”
It Also Resets Your Rate for Fat Burning
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Ozempic also targets the centers in the brain that resets a person’s set rate for fat, Dr. Decotiis says. “When your set rate is higher for fat, you tend to hold more weight. When people go on Ozempic it resets the amount of weight that your body wants to hold onto.”
It Improves Insulin Function
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The main way Ozempic works is changing the way insulin works, explains Dr. Decotiis. “When insulin works well, you can burn fat, when it doesn’t you gain weight,” she says.
It Helps Regulate Hormones
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“It helps regulate people’s hormones that have changed due to aging, stress, etc., so that they can lose weight,” she continues. “When people age their hormones change and it’s harder for them to lose weight. Ozempic stimulate the hormones needed in the body for fat loss.”
It Can Help with Self-Esteem and Rarely Leads to Depression
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Dr. Decotiiis has seen a lot of positive effects on personality in her practice. “When people lose weight, they have better self-esteem, and they feel more confident in their own skin,” she says. “I have people who were using sedatives for anxiety or depression, and then when they took these drugs, they felt better and didn’t need them as much. My patient who had ADHD felt they had better focus and concentration. I have never had anyone who’s gone into depression or has felt worse after taking these drugs. My advice is to know who the patient is and supervise them accordingly.”
Ozempic Is Actually Only Approved for Those with Type 2 Diabetes
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According to the National Library of Medicine Ozempic is approved to control blood sugar levels in adults with type 2 diabetes when other medications do not control the sugar levels well enough.
It Can Also Help with Heart Health
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It is also used to reduce the risk of a stroke, heart attack, or death in adults who have type 2 diabetes along with heart and blood vessel disease. “It is not used to treat type 1 diabetes or diabetic ketoacidosis,” they say.
Wegovy Is Approved for Weight Loss
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“Semaglutide injection (Wegovy) is used to reduce the risk of a stroke, heart attack, or death in adults who are overweight or obese along with heart and blood vessel disease,” they say, adding that  “used along with an individualized low-calorie, low-fat diet and exercise program” it can help with weight loss “in obese adults or overweight adults who may also have high blood pressure, diabetes, or high cholesterol” and in obese children 12 years of age or older.
It Comes in a Prefilled Pen
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Semaglutide injection comes in a prefilled dosing pen injected once a week under the skin. “Use semaglutide injection on the same day each week at any time of day. You may change the day of the week that you use semaglutide as long as it has been 2 or more days (48 or more hours) since you used your last dose,” they say.
RELATED:What Happens to Your Body When You Stop Taking Ozempic
You Usually Start on a Low Dosage and Work Your Way Up
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Your doctor usually gets you started on a lower dosage, increasing it after four weeks. “Your doctor may increase your dose again after another four weeks based on your body's response to the medication,” they say.
Most Common Side Effects
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These are the most common side effects of Ozempic and Wegovy:
nausea
vomiting
diarrhea
abdominal pain
constipation
heartburn
burping
More Serious Side Effect
Shutterstock
There are also some potential serious side effects:
ongoing pain that begins in the upper left or middle of the stomach but may spread to the back, with or without vomiting
rash; itching; swelling of the eyes, face, mouth, tongue, or throat; or difficulty breathing or swallowing
decreased urination; or swelling of legs, ankles, or feet
vision changes
fainting or dizziness
pain in upper stomach; yellowing of skin or eyes; fever; or clay-colored stools (in those receiving semaglutide [Wegovy] for management of weight loss)
rapid heartbeat
dizziness, light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety or irritability or mood changes, hunger, weakness, or feeling jittery
RELATED:5 Foods That Maximize Weight Loss on GLP-1 Medicines, According to Coach
How Much Does Ozempic Cost?
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Just because your doctor prescribes Ozempic doesn’t mean insurance will cover it. The cost of Ozempic weighs heavily on whether your health insurance company believes that you qualify for the drug.
It’s Very Expensive Without Insurance
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Ozempic is expensive if your insurance refuses to cover it. According to GoodRX, without insurance Ozempic can cost as little as $937.98 per month and as much as $1,014 per month.
How Much Does Ozempic Cost with Insurance
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How much does it cost with insurance? Novo also offers a savings card, which enables people with private or commercial insurance to pay as little as $25 for a 1-month, 2-month, or 3-month supply of Ozempic for up to 24 months. However, many people pay more than that, with most insurance companies covering around 85 percent of the cost.
How Much Profit Are the Drug Companies Making?
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According to a study published in JAMA Network Open Trusted Source, these drugs “can likely be manufactured for prices far below current prices, enabling wider access.” Researchers from Yale University, King’s College Hospital in London, and the nonprofit Doctors Without Borders concluded that if the producers were charging $0.89 to $4.73 a month and still making a profit. This is in contrast to the nearly $1,000 per month list price charged by Novo Nordisk for Ozempic in the US.
RELATED:15 Things to Know Before Getting Ozempic for Weight Loss
What Is Rebound Weight Gain?
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After you stop taking Ozempic, there is a good chance you may gain the weight back. One study found that one year after stopping the drug, participants regained two-thirds of their prior weight loss.
Ozempic Face
Shutterstock
"Ozempic face" is one of the most popularized side effects of GLP-1 drugs. It’s actually a side effect of rapidly losing weight and isn’t a direct result of the drug. Losing weight fast can cause facial aging, including a hallowed look, wrinkles, and sunken eyes, explains Harvard Health.
RELATED: 15 Travel Habits That Help You Stay Fit and Lose Weight on the Go
Loose Skin and Excess Fat
Shutterstock
“Ozempic body” and “Ozempic butt” are two more trending terms to describe the sagging skin left behind as a result of rapid weight loss. After dropping weight fast, loose skin, pockets of stubborn fat, and stretch marks can be left behind. Treatments, including surgery, like liposuction and tummy tucks, and less invasive options, like CoolSculpting and EmSculpt Neo, as well as lasers, can help treat these conditions.
Nutrition & Diet
        Expert Reveals 5 Hidden Ozempic and Wegovy Mistakes to Avoid Now
    
Copyright Dr. Brian Yeung, ND/YouTube/Shutterstock
By Christopher RobackJan 08, 2025
Christopher Roback
Professional Health, Science Editor and Writer
Christopher Roback is an experienced news journalist specializing in political, science, and crime news.
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Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.
We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.
Starting Ozempic or Wegovy can feel overwhelming, and many patients make critical mistakes that could affect their results. "These medications work differently from traditional treatments, and understanding how to use them correctly is crucial," explains Dr. Brian Yeung, ND, who specialize in metabolic health. With the rising popularity of GLP-1 medications for managing diabetes and weight loss, avoiding common pitfalls becomes even more important. Here are the five key mistakes to watch out for, along with expert guidance on how to prevent them.
Skipping or Inconsistent Dosing"Consistency is crucial with GLP-1 medications," says Dr. Yeung in his video. According to Cleveland Clinic, each medication has a specific dosing schedule - some require weekly injections while others are daily. Missing doses can interrupt your progress and reduce the medication's effectiveness. Set reminders and establish a routine to stay on track.
RELATED: 20 Things You Need to Know About Ozempic and Weight Loss
Ignoring Diet and HydrationShutterstock
"Many patients don't realize these medications slow down digestion, which means you need to adjust your eating habits," Dr. Yeung points out. Cleveland Clinic confirms that GLP-1 agonists work by slowing stomach emptying and increasing feelings of fullness. Stay hydrated and focus on nutrient-rich foods to prevent potential deficiencies.
Not Monitoring Blood Sugar ProperlyShutterstock
"While these medications have a lower risk of causing hypoglycemia, regular monitoring is still essential," says Dr. Yeung. Cleveland Clinic experts warn that the risk increases when combining GLP-1s with other diabetes medications. Keep track of your blood sugar levels and know the signs of low blood sugar, which include shaking, sweating, and dizziness.
Dismissing Side EffectsShutterstock
"Some initial digestive issues are common, but they shouldn't be severe or ongoing," Dr. Yeung advises. According to Cleveland Clinic, common side effects include nausea, vomiting, and diarrhea, particularly when starting the medication or increasing the dose. Don't ignore persistent or severe symptoms - contact your healthcare provider if side effects become concerning.
RELATED:20 Possible Ozempic Side Effects
Relying Solely on MedicationShutterstock
"The biggest mistake is thinking these medications work in isolation," Dr. Yeung emphasizes. Cleveland Clinic stresses that GLP-1 agonists are just one part of a comprehensive treatment plan. Successful management requires combining medication with lifestyle changes, proper diet, and regular exercise.
Understanding Your MedicationShutterstock
Cleveland Clinic notes that GLP-1 medications work by mimicking a natural hormone that helps control blood sugar and appetite. Understanding this mechanism can help you use the medication more effectively and set realistic expectations for your treatment journey.
Tracking Progress EffectivelyShutterstock
Monitor more than just weight loss. Cleveland Clinic reports that GLP-1 medications can offer additional benefits, including improved blood pressure and better lipid profiles. Keep track of these various health markers to get a complete picture of your progress.
RELATED:What Happens to Your Body When You Stop Taking Ozempic
When to Contact Your DoctorShutterstock
Cleveland Clinic recommends maintaining regular check-ups and promptly reporting any persistent side effects or concerns about the medication's effectiveness. Don't wait until small issues become major problems. And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.
Nutrition & Diet
        9 Key Differences Between Ozempic and Other GLP-1 Meds for Weight Loss
    

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By Leah GrothJun 26, 2024
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Leah Groth has decades of experience covering all things health, wellness and fitness related. 
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Ozempic is the buzziest drug in the weight loss world. However, it isn’t the only GLP-1 drug people are using to lose weight fast. Before you try and get a prescription, there are a lot of things you need to know about the drug, including how it works and also how it compares to similar treatments on the market. Here are ten key differences between Ozempic and other GLP-1 meds for weight loss, according to triple-board-certified plastic surgeon Leo Lapuerta, MD, The Plastic Surgery Institute of Southeast Texas.
Ozempic Isn’t Even Approved for General Weight Loss
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While Ozempic is probably the most well-known GLP-1, it isn’t technically even approved for general weight loss. “It is for the control of Type 2 diabetes,” Dr. Lapuerta reveals.
Most Weight Loss Drugs Aren’t Approved for Weight Loss
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In fact, most drugs being used for weight loss weren’t even intended for that purpose. “Most of the GLP-1 drugs like Rybelsus, Victoza, Trulicity, and Byetta are intended for the treatment of Type 2 diabetes with beneficial side effects that include weight loss,” explains Dr. Lapuerta.
RELATED:20 Possible Ozempic Side Effects
Some GLP-1s Offer Heart and Kidney Benefits
Shutterstock
There are other benefits to taking weight loss drugs. “Ozempic, Victoza, and Trulicity all have benefits for the heart and kidneys in addition to control of Type 2 diabetes,” says Dr. Lapuerta.
One Weight Loss Drug Is Injected Daily, Most of Them Are Weekly
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Most of the GLP-1s, including Ozempic, require a weekly injection. However, “Victoza is unique because it is injected daily rather than weekly,” says Dr. Lapuerta.
One Is Available in Oral Format
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And not all of them require a needle. “Rybelsus is the only GLP-1 that is available in oral format as all the other options are by injection only,” says Dr. Lapuerta.
RELATED:What Happens to Your Body When You Stop Taking Ozempic
Some of Them Are Approved for Weight Loss and Weight Management
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Ironically, while the most well-known of the bunch isn’t even approved for weight loss, the majority of the others are. “Wegovy, Saxenda, and Mounjaro (Tirzepatide) are GLP-1 agonists intended for weight loss and weight management rather than the treatment of Type 2 diabetes,” says Lapuerta.
Some Are More Effective Than Others
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According to Dr. Lapuerta, results vary by brand. “Wegovy typically produces 2 to 3 times the percent weight loss as Saxenda,” he maintains.
Only One of Them Includes GIP
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Mounjaro (Tirzepatide) has an edge over the competition. “It is the first GLP-1 to also include GIP, glucose-dependent insulinotropic polypeptide (GIP), another gut hormone agonist that provides better longer-term control of blood sugar as indicated by better reductions in Hemoglobin A1C levels,” says Dr. Lapuerta.
RELATED:20 Things to Avoid While on Ozempic
Some Medications Have Two Names
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Don’t let names deceive you. “Zepbound is the FDA-approved version of Mounjaro specifically for weight loss,” says Dr. Lapuerta.
Keep Reading About Ozempic
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Keep educating yourself about Ozempic. Here are 15 things you should know before getting Ozempic for weight loss. And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.
Nutrition & Diet
        4 Weight Loss “Solutions” That Are Part of the Problem
    

        She Has a Flat Tummy in Her 50s Because of These 4 Habits
    

        Copyright lois.hughey.coaching/Instagram
    
By Leah GrothMar 11, 2025
Leah Groth
Writer, Editor, and Content Creator
Leah Groth has decades of experience covering all things health, wellness and fitness related. 
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✓Evidence-Based
This content references scientific studies and academic research, and is fact-checked to ensure accuracy.
Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.
We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

	Are you doing everything you think you should to lose weight, but the pounds aren’t falling off? Lois Hughey is a weight loss warrior and coach who lost 15 pounds and kept it off. Now, she makes it her mission to help women over 50 “simplify nutrition and fitness” and regularly offers tips for sustainable fat loss in menopause on her social media feeds. In a new post, she reveals weight loss “solutions” that are actually part of the problem. “I swear my body changed overnight in my late 40s, and trust me—I tried all the ‘solutions.’ (Hint: none of them worked.)” she writes. She also reveals a few things to do instead to help you lose weight.

            
                You Can’t Just “Eat Less”
            
            
        
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A post shared by Lois Hughey • Menopause • Nutrition •Fat Loss Coach (@lois.hughey.coaching)
First, you can’t just “eat less,” she says. “A caloric deficit is key, but if you’ve been dieting forever, eating less won’t fix your midlife metabolism. It just leads to cravings, exhaustion, and that “start over Monday” cycle. You can pull this off for a while but once you decide you are tired of feeling terrible, you go right back to eating more and regain whatever weight you lost. Keeping you stuck in a cycle of gaining and losing the same five-10 pounds over and over again,” she writes.
RELATED:30 Best Protein Foods That Melt Fat Almost Instantly

            
                You Might Need to Move More, But Maybe Not
            
            
        
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A post shared by Lois Hughey • Menopause • Nutrition •Fat Loss Coach (@lois.hughey.coaching)
“You might need to ‘move more’… or not,” she continues. “You cannot cardio your way to sustainable fat loss. Without strength training, too much cardio (without a balanced approach that includes strength training) will leave you under-muscled and hungry.”

            
                You Can’t Rely on Simply Cutting Carbs
            
            
        
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A post shared by Lois Hughey • Menopause • Nutrition •Fat Loss Coach (@lois.hughey.coaching)
“Cutting carbs won’t save you,” she explains. “Carbs are energy (and happiness!). No solid data says low carb helps healthy women in midlife lose fat faster.”

            
                You Can’t Just Add More of X
            
            
        
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Also, “Adding more of X (protein, carbs, workouts, meals, snacks) won’t work without a strategy,” she says. “More isn’t better if you don’t understand what your body actually needs.”
RELATED:10-Min Walking Workout Burns Fat at Home, Says Coach

            
                What to Do Instead: Make Sure Your Body Is Metabolically Healthy
            
            
        
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A post shared by Lois Hughey • Menopause • Nutrition •Fat Loss Coach (@lois.hughey.coaching)
What should you do instead? “Make sure your body is in a metabolically healthy place before you start cutting calories. This means good sleep, digestion, mood, energy and eating enough protein and overall calories before you try to lose fat,” she writes.

            
                Walk and Lift Weights
            
            
        
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A post shared by Lois Hughey • Menopause • Nutrition •Fat Loss Coach (@lois.hughey.coaching)
Next, get your steps in. “Walk a minimum of 8000 steps a day and strength train 2-3 times a week. If you love cardio, add it in on top of that (allowing for some rest, too)” she writes. 

            
                Focus on Whole, Minimally Processed Carbs
            
            
        
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A post shared by Lois Hughey • Menopause • Nutrition •Fat Loss Coach (@lois.hughey.coaching)
You can eat carbs, but keep it healthy. “Keep 80% of your carbs whole, and minimally processed. Nuts, grains, seeds, veggies, and whatever fruit you want. The other 20% can be fun!” she writes.
RELATED:17 Pre-Meal Foods That Burn Fat Like Ozempic, According to an Expert

            
                Add Protein
            
            
        
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A post shared by Lois Hughey • Menopause • Nutrition •Fat Loss Coach (@lois.hughey.coaching)
“You may need to add more protein. You may need to add in a balanced snack. But if you add (even the good stuff) and go over your caloric needs, you will still gain weight. Add wisely,” she concludes. And if you enjoyed this article, don't missthese 8 High-Protein Foods with Nearly Zero Calories That Melt Fat.
Nutrition & Diet
        5 Things You Need to Do to Lose Weight Over 40
    

        5 Protein Diet Traps Women Over 35 Need to Avoid for Real Fat Loss
    

        Copyright fedandfreewithsarahb/Instagram
    
By John-Chapple1Mar 11, 2025
John-Chapple1
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✓Expert-Recommended
We've consulted with our team of licensed nutritionists              and dietitians to bring you informed recommendations for food products, health aids and nutritional goods to                safely and successfully guide you toward making better diet and nutrition choices. We strive to only recommend                  products that adhere to our philosophy of eating better while still enjoying what you eat.
Many people believe that carbs are the enemy in terms of weight loss. However, this isn’t true. Sarah Bouchard is a Nutrition Coach & Educator who helps women over 35 “ditch diet confusion & simplify nutrition” for “Sustainable fat loss + healthy body composition,” she explains in her Instagram bio. In a new social media post, she reveals that at 40, she finally shifted her approach to nutrition and fixed some crucial carb mistakes. Here is what she did instead. 

            
                She Spent Years Avoiding Carbs
            
            
        
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A post shared by Sarah Bouchard | Fat-Loss Coach & Educator (@fedandfreewithsarahb)
“I spent years not eating foods like bananas or potatoes, thinking they would spike my glucose and make me gain weight, yet I: couldn’t figure out why I gained weight, didn’t look ‘toned’ despite working out, was constantly exhausted, had regular binges & had out of control cravings,” she writes.
RELATED:17 Pre-Meal Foods That Burn Fat Like Ozempic, According to an Expert

            
                This Impacted Her Metabolism
            
            
        
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A post shared by Sarah Bouchard | Fat-Loss Coach & Educator (@fedandfreewithsarahb)
“Why? I didn’t have a healthy metabolism DESPITE eating a clean low-carb diet & working out. Because I: wasn’t eating enough protein, was eating too much fat/too many calories, wasn’t moving enough throughout the day, and drank alcohol regularly which wrecked my sleep,” she says. 

            
                She Is Now the “Healthiest and Strongest” She Has Been at 40
            
            
        
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A post shared by Sarah Bouchard | Fat-Loss Coach & Educator (@fedandfreewithsarahb)
“I’m now 40 and can proudly say I’m the healthiest and strongest I’ve ever been in my life, & I eat over 200g of carbs a day!” she continues. “The real key to metabolic health isn’t cutting carbs—it’s optimizing muscle, movement, sleep, & food quality. Here’s what actually improves insulin sensitivity (backed by science).”

            
                Build Muscle
            
            
        
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A post shared by Sarah Bouchard | Fat-Loss Coach & Educator (@fedandfreewithsarahb)
The first thing that improves insulin sensitivity is building muscle. “Muscle is like a glucose sponge—it pulls sugar out of your blood, reducing the need for insulin. Resistance training 2–3x per week improves insulin sensitivity by increasing glucose uptake (PMID: 23970530). Prioritize progressive overload to see the best results,” she says.
RELATED:10 Foods to Avoid If You're Trying to Burn Fat, Says Expert

            
                Move Daily (Beyond the Gym)
            
            
        
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A post shared by Sarah Bouchard | Fat-Loss Coach & Educator (@fedandfreewithsarahb)
Next, in addition to workouts, you should move daily. “Long sitting hours = reduced insulin sensitivity. Break up sitting every 30 mins with ‘movement snacks’ (e.g., air squats, stair climbs). Even a 5-min post-meal walk lowers blood sugar & insulin response (PMID: 19207879),” she writes.

            
                Prioritize Sleep:
            
            
        
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A post shared by Sarah Bouchard | Fat-Loss Coach & Educator (@fedandfreewithsarahb)
She also stresses the importance of prioritizing sleep. “Lack of sleep disrupts insulin function. Less than 6 hours/night? Your body responds as if it’s prediabetic (PMID: 20371664). Aim for 7–9 hours of quality sleep, stick to a schedule, & limit blue light before bed, she says.

            
                Eat Mostly Whole-Food Carbs
            
            
        
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A post shared by Sarah Bouchard | Fat-Loss Coach & Educator (@fedandfreewithsarahb)
Finally, “It’s not carbs—it’s the type of carbs,” she says. “Whole grains, fruits, veggies, and legumes digest slower, keeping blood sugar steady (PMID: 11976158). Stick to mostly whole food carbs that are full of fiber and water & keep the ‘fun carbs’ around 5-20% within calorie balance!” she writes. 

            
                Be More Strategic
            
            
        
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A post shared by Sarah Bouchard | Fat-Loss Coach & Educator (@fedandfreewithsarahb)
The bottom line? “Fixing your metabolism isn’t about fear—it’s about strategy. Lift weights, move often, sleep well, and eat whole foods. Small shifts = big results,” she says. And if you enjoyed this article, don't missthese 8 High-Protein Foods with Nearly Zero Calories That Melt Fat.

        Lose Up to 16 Pounds by Summer by Investing in These 5 Simple Items Recommended by a Perimenopause Expert
    

        Coach Lost 23 Pounds in 7 Months with This Step-by-Step Plan
    

        Copyright liftwithtrish/Instagram
    
By Leah GrothMar 10, 2025
Leah Groth
Writer, Editor, and Content Creator
Leah Groth has decades of experience covering all things health, wellness and fitness related. 
 See Full Bio 
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Are you on a mission to lose weight by summer? Investing in yourself and some tools to help you achieve your goals might be the thing to do. Trish Koeslag is a women’s nutrition and fitness coach whose mission is to help women over 40 simplify macros and movement to lose weight. In a new social media post, she shares a few things to invest in in order to lose weight fast. “Here’s the exact plan to lose 8 to 16 pounds by the summer for ladies in perimenopause,” she writes. 

            
                She Invested in Herself
            
            
        ​Eat Whole Foods 90 Percent of the TimeCopyright liftwithtrish/Instagram“I invested in myself. And yes, I had to spend a little bit of money but the ROI has been nothing short of extraordinary. These 5 simple items can change your life around. Let’s welcome summer 2025 feeling our most bad selves!”

            
                Get a Food Scale
            
            
        ​Lift WeightsCopyright liftwithtrish/InstagramThe first thing you need? “Get yourself a food scale and start weighing and tracking your food in grams. This will help you accurately measure how much food you’re eating. I’ve been testing out Cronometer and think it’s a great app for food tracking!” she writes.

            
                And, Lift Weights
​Get Enough SleepCopyright liftwithtrish/InstagramIn addition to prioritizing your diet, make sure to exercise. “Pair your nutrition with a strength training routine-train 3-4x/week!” she encourages.

            
                Grab a 2 Liter Water Bottle
            
            
        ​Track Everything You EatCopyright liftwithtrish/InstagramHydration is also key. “Grab a 2L water bottle and fill it up every morning; take it with you wherever you go. Water flushes out toxins, reduces water retention, improves workout performance, helps control snacking,” she writes.

            
                Stock Up on Meal Prep Containers
            
            
        ​Lift WeightsCopyright liftwithtrish/Instagram“Stock up on meal prep containers,” she urges. “If you prep food ahead of time, and plan your meals for the day ahead of time, it will make it so much easier to stick to your nutrition goals. Choose 90% whole foods at all meals!”

            
                Invest in a Fitness Tracker
            
            
        ​Get Yourself in a DeficitCopyright liftwithtrish/InstagramNext, “look into fitness trackers and invest,” she says. “This will help ensure you are getting enough steps in, and will monitor your overall activity levels. Are fitness trackers spot-on accurate? Nope! But,it can set a baseline for you!”

            
                And, Use It to Get Your Steps In
            
            
        Trish Koeslag Pops the Lid on 2 “Dieting Myths” That Kept Her From Losing 15 PoundsCopyright liftwithtrish/InstagramThe fitness tracker is a great tool for tracking your steps. “Aim for 10K/day. And throw in a couple of days of cardio—try two days for 30 minutes!” she writes.

            
                Get a Journal
            
            
        ​HydrateCopyright liftwithtrish/InstagramHer last item to invest in? “Spend a few bucks on a journal and take 5-10 minutes every morning to set your intentions for the day. This doesn’t mean your day will be perfect but in my personal journey, setting my intentions for the day always gets my mind in the right place,” she encourages. And if you enjoyed this article, take advantage of these 15 Quick Ways to Lose Body Fat Percentage in a Week.
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