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This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

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We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

7 Things You Must Know Before Starting Semaglutide

Essential safety advice from a physician who prescribes it.

Christopher Roback
By Christopher RobackApr 27, 2025
Christopher Roback
Health & Wellness Writer | Author | Exclusive Contributor at Body Network
Christopher Roback is a health and wellness writer and exclusive contributor to Body Network.
See Full Bio
✓Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

Christy Risinger, MD
Copyright Christy Risinger, MD/YouTube
Christopher Roback
By Christopher RobackApr 27, 2025
Christopher Roback
Health & Wellness Writer | Author | Exclusive Contributor at Body Network
Christopher Roback is a health and wellness writer and exclusive contributor to Body Network.
See Full Bio
✓Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

Nutrition & Diet

The growing popularity of weight loss medications has created both opportunities and challenges for patients. Finding safe, effective treatments at reasonable prices isn't always straightforward. Christy Reisinger, MD, a General Internal Medicine Physician, has guided countless patients through this process. "There's been so much misinformation that's been given to the public," explains Dr. Christy, who wants to clear up confusion around these medications. Before you start semaglutide therapy, here are seven critical factors to consider for your safety and success.

Research your pharmacy thoroughly

When considering compounded semaglutide, verifying your pharmacy's credentials is non-negotiable. "I did my research, and you can too," Dr. Christy says in her post. She specifically recommends using the BeSafeRx tool to investigate potential pharmacies before making your decision. This resource reveals if a pharmacy has faced safety concerns or regulatory issues in the past. Dr. Christy even mentions, "There's actually a compounding pharmacy that I refuse to use because it's had several safety concerns."

RELATED: 15 Things to Know Before Requesting Ozempic for Weight Loss

Confirm sterile compounding practices

Pen,Injection,Semaglutide,Ozempic, diabetes, medicine, medication, diet, weight, loss​Mental Clarity and Reduced Food NoiseShutterstock

Injectable medications require strict sterile protocols to prevent contamination and infection. "Because semaglutide is an injectable medication, it needs to be made under a sterile hood in sterile conditions, and that's really important," Dr. Christy emphasizes. When speaking with your provider, specifically ask if they work exclusively with sterile compounding pharmacies. This seemingly small detail can make an enormous difference in medication safety and in reducing potential complications.

Beware of financial incentives

Pharmacy,Drugstore:,Beautiful,Asian,Pharmacist,Uses,Checkout,Counter,Computer,,Does​ How Much Lysine You Need DailyShutterstock

Your provider should have your best interests at heart, not profit motives. "I don't receive any money or kickbacks when I write a prescription for compounded semaglutide," Dr. Christy states firmly. She explains that the proper process involves patients paying pharmacies directly, with physicians receiving no financial benefit from these transactions. "If your doctor or your med spa or wherever you're getting your compounded medication is getting benefit monetarily from it, I would be wary," she cautions.

Ask about ingredient sourcing

Valparaiso, IN USA - January 22, 2024: Wegovy semaglutide pens for treatment of chronic obesity, close up​Combining Natural GLP-1 Boosters for Maximum ResultsShutterstock

Not all semaglutide is created equal, and quality control matters significantly. Dr. Christy notes that reputable "compounding pharmacies are getting semaglutide from FDA-registered facilities." This ensures pharmaceutical-grade ingredients rather than questionable alternatives. When discussing treatment with your provider, ask specifically where they recommend that you obtain semaglutide. Any hesitation or vague answers should raise immediate concerns about quality and safety.

RELATED:20 Possible Ozempic Side Effects

Question added ingredients

Medicine,,Healthcare,And,People,Concept,-,Female,Doctor,With,Tablet​Check In Regularly with Your DoctorShutterstock

Simple formulations tend to be safer when it comes to compounded medications. "I don't add anything to semaglutide," says Dr. Christy. She explains that while some providers mix in vitamin B12 or other additives, "we don't really know how other ingredients will interact with the semaglutide." Requesting pure semaglutide without additional components can reduce potential interactions and keep your treatment protocol straightforward and easier to monitor.

Understand reasonable pricing

Young woman with wallet and money in boutique, closeupShutterstock

Affordability drives many patients toward compounded options, but extreme bargains should trigger suspicion. "Whereas Wegovy and Ozempic without a coupon cost about $1,200 a month, compounded semaglutide tends to be around $300 a month," Dr. Christy explains. She specifically warns against "bargain basement" prices, noting, "I think realistically, you should be spending a couple of hundred dollars a month to get it from a reputable compounding source." Unusually low prices often indicate corners being cut.

Consult with obesity medicine specialists

Doctor measuring obese man waist body fat. Obesity and weight loss

Shutterstock

Generic weight loss advice can't replace specialized medical expertise. "Please don't buy semaglutide from an online source without talking with knowledgeable physicians, preferably trained in obesity medicine," urges Dr. Christy. These specialists understand proper dosing protocols, potential side effects, and how to integrate medication into comprehensive treatment plans. Dr. Christy emphasizes that "there are ways to use these medications well and then there are ways to use them in an unsafe way," highlighting the importance of professional guidance.

RELATED:What Happens to Your Body When You Stop Taking Ozempic

Conclusion

Portrait of depressed woman sitting alone at home and looking away with sad expression holding hands on chin, deep thoughts feeling lonely. Frustrated blonde female pondering make difficult choice.11 Signs Ozempic Is Not for YouShutterstock

Navigating the world of weight management medications requires careful consideration of safety, quality, and proper medical supervision. By following these seven essential guidelines from Dr. Christy Reisinger, you can make more informed decisions about semaglutide treatment. Remember that even with compounded versions, professional medical oversight remains crucial throughout your treatment journey. And if you enjoyed this article, don't miss20 Incredible Ozempic Success Stories of All Time.

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Nutrition & Diet

7 Things You Must Know Before Starting Semaglutide

Christy Risinger, MD
Copyright Christy Risinger, MD/YouTube
Christopher Roback
By Christopher RobackApr 27, 2025
Christopher Roback
Health & Wellness Writer | Author | Exclusive Contributor at Body Network
Christopher Roback is a health and wellness writer and exclusive contributor to Body Network.
See Full Bio
✓Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

The growing popularity of weight loss medications has created both opportunities and challenges for patients. Finding safe, effective treatments at reasonable prices isn't always straightforward. Christy Reisinger, MD, a General Internal Medicine Physician, has guided countless patients through this process. "There's been so much misinformation that's been given to the public," explains Dr. Christy, who wants to clear up confusion around these medications. Before you start semaglutide therapy, here are seven critical factors to consider for your safety and success.

Research your pharmacy thoroughly

When considering compounded semaglutide, verifying your pharmacy's credentials is non-negotiable. "I did my research, and you can too," Dr. Christy says in her post. She specifically recommends using the BeSafeRx tool to investigate potential pharmacies before making your decision. This resource reveals if a pharmacy has faced safety concerns or regulatory issues in the past. Dr. Christy even mentions, "There's actually a compounding pharmacy that I refuse to use because it's had several safety concerns."

RELATED: 15 Things to Know Before Requesting Ozempic for Weight Loss

Confirm sterile compounding practices

Pen,Injection,Semaglutide,Ozempic, diabetes, medicine, medication, diet, weight, loss​Mental Clarity and Reduced Food NoiseShutterstock

Injectable medications require strict sterile protocols to prevent contamination and infection. "Because semaglutide is an injectable medication, it needs to be made under a sterile hood in sterile conditions, and that's really important," Dr. Christy emphasizes. When speaking with your provider, specifically ask if they work exclusively with sterile compounding pharmacies. This seemingly small detail can make an enormous difference in medication safety and in reducing potential complications.

Beware of financial incentives

Pharmacy,Drugstore:,Beautiful,Asian,Pharmacist,Uses,Checkout,Counter,Computer,,Does​ How Much Lysine You Need DailyShutterstock

Your provider should have your best interests at heart, not profit motives. "I don't receive any money or kickbacks when I write a prescription for compounded semaglutide," Dr. Christy states firmly. She explains that the proper process involves patients paying pharmacies directly, with physicians receiving no financial benefit from these transactions. "If your doctor or your med spa or wherever you're getting your compounded medication is getting benefit monetarily from it, I would be wary," she cautions.

Ask about ingredient sourcing

Valparaiso, IN USA - January 22, 2024: Wegovy semaglutide pens for treatment of chronic obesity, close up​Combining Natural GLP-1 Boosters for Maximum ResultsShutterstock

Not all semaglutide is created equal, and quality control matters significantly. Dr. Christy notes that reputable "compounding pharmacies are getting semaglutide from FDA-registered facilities." This ensures pharmaceutical-grade ingredients rather than questionable alternatives. When discussing treatment with your provider, ask specifically where they recommend that you obtain semaglutide. Any hesitation or vague answers should raise immediate concerns about quality and safety.

RELATED:20 Possible Ozempic Side Effects

Question added ingredients

Medicine,,Healthcare,And,People,Concept,-,Female,Doctor,With,Tablet​Check In Regularly with Your DoctorShutterstock

Simple formulations tend to be safer when it comes to compounded medications. "I don't add anything to semaglutide," says Dr. Christy. She explains that while some providers mix in vitamin B12 or other additives, "we don't really know how other ingredients will interact with the semaglutide." Requesting pure semaglutide without additional components can reduce potential interactions and keep your treatment protocol straightforward and easier to monitor.

Understand reasonable pricing

Young woman with wallet and money in boutique, closeupShutterstock

Affordability drives many patients toward compounded options, but extreme bargains should trigger suspicion. "Whereas Wegovy and Ozempic without a coupon cost about $1,200 a month, compounded semaglutide tends to be around $300 a month," Dr. Christy explains. She specifically warns against "bargain basement" prices, noting, "I think realistically, you should be spending a couple of hundred dollars a month to get it from a reputable compounding source." Unusually low prices often indicate corners being cut.

Consult with obesity medicine specialists

Doctor measuring obese man waist body fat. Obesity and weight loss

Shutterstock

Generic weight loss advice can't replace specialized medical expertise. "Please don't buy semaglutide from an online source without talking with knowledgeable physicians, preferably trained in obesity medicine," urges Dr. Christy. These specialists understand proper dosing protocols, potential side effects, and how to integrate medication into comprehensive treatment plans. Dr. Christy emphasizes that "there are ways to use these medications well and then there are ways to use them in an unsafe way," highlighting the importance of professional guidance.

RELATED:What Happens to Your Body When You Stop Taking Ozempic

Conclusion

Portrait of depressed woman sitting alone at home and looking away with sad expression holding hands on chin, deep thoughts feeling lonely. Frustrated blonde female pondering make difficult choice.11 Signs Ozempic Is Not for YouShutterstock

Navigating the world of weight management medications requires careful consideration of safety, quality, and proper medical supervision. By following these seven essential guidelines from Dr. Christy Reisinger, you can make more informed decisions about semaglutide treatment. Remember that even with compounded versions, professional medical oversight remains crucial throughout your treatment journey. And if you enjoyed this article, don't miss20 Incredible Ozempic Success Stories of All Time.

Nutrition & Diet

This Doctor Reveals 5 Alternative Medications When You Can't Get Ozempic

Ozempic shutterstock_1404723482
Shutterstock
Christopher Roback
By Christopher RobackNov 14, 2024
Christopher Roback
Health & Wellness Writer | Author | Exclusive Contributor at Body Network
Christopher Roback is a health and wellness writer and exclusive contributor to Body Network.
See Full Bio
✓Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

Struggling to find your prescribed weight-loss medication? You're not alone. With widespread shortages of popular medications like Ozempic and Wegovy, many patients are searching for alternatives. Here's what you need to know about your options, according to an experienced physician.

Dr. Christy Risinger, a Board-Certified Internal Medicine Physician with nearly two decades of experience in primary care, shares vital information about GLP-1 medications and their alternatives that could help you maintain your treatment plan.

The Evolution of Weight Loss Medications

"GLP-1 medications have been around since 2005, starting with Exenatide, also known as Byetta," explains Dr. Risinger. She notes that the early medications showed promising results: "With Byetta, people experienced about a six-pound weight loss and their blood sugar reduced by 0.9%." This marked the beginning of a revolutionary change in weight management and diabetes treatment.

RELATED:20 Things You Need to Know About Ozempic and Weight Loss

Why Newer Medications Are Hard to Find

Pharmacy,Drugstore:,Beautiful,Asian,Pharmacist,Uses,Checkout,Counter,Computer,,DoesShutterstock

"Ozempic and Wegovy are getting so much attention because they work the best among GLP-1 medications," explains Dr. Risinger. She points out that even newer medications like Zepbound and Mounjaro have shown more impressive results: "Mounjaro reduces blood sugar by two to two and a half percent, and when rebranded as Zepbound for weight loss, patients lost a whopping average of 50 pounds, which is just incredible."

What You Need to Know About Zepbound (Tirzepatide)

Zepbound injection pen from Eli Lilly is an injectable prescription medicine that may help adults with obesity, or with excess weight (overweight) Copenhagen, Denmark - November 9, 2023.Shutterstock

Zepbound was approved for weight loss in late 2023 and contains tirzepatide as its active ingredient, according to NBC. In a head-to-head study with semaglutide published in JAMA Internal Medicine, patients taking Zepbound lost more weight - around 21% of body weight over 72 weeks compared to 15% for Wegovy users. The study analyzed records from over 41,000 adults and found consistently higher weight loss percentages with tirzepatide at 3, 6, and 12 months.

What You Need to Know About Mounjaro (Tirzepatide)

Basrah, Iraq - November 24, 2023: photo of Mounjaro Weight Loss Pen in handShutterstock

Per WebMD, Mounjaro is a prescription medication containing tirzepatide used to lower blood sugar in type 2 diabetes patients. It works by increasing insulin production when blood sugar rises, preventing liver sugar release, and slowing food absorption. The medication comes in various dose strengths from 2.5mg to 15mg in prefilled pens and requires refrigeration for storage.

Understanding Your Alternative Options

Victoza Insulin group emerging from a medication for diabetes patients. studio shot on a white background in Viktoza box. Diabetes drugs.Shutterstock

If you can't access Ozempic, Dr. Risinger outlines several alternatives: "You can talk to your doctor about earlier-generation medications like Byetta, Bydureon, and Victoza." While these medications may require daily rather than weekly injections, they can be effective interim solutions.

RELATED:20 Possible Ozempic Side Effects

What You Need to Know About Byetta (Exenatide)

Istanbul Turkey 27 April 2024; BD Micro Fine plus Pen Needle 0.25 mm (31G) x 6 mm. It is an insulin pen needle. It is sold in boxes of 100 pieces.Shutterstock

According to WebMD, Byetta contains exenatide and is used for treating type 2 diabetes. It works through three mechanisms: stimulating insulin release after meals, preventing liver sugar release, and slowing food movement through the body. It's available in 5mcg and 10mcg prefilled pens and must be used within an hour before morning and evening meals.

What You Need to Know About Bydureon BCise (Exenatide)

BYDUREON BCise Type 2 Diabetes Treatment Insulin injection pen or insulin cartridge pen for diabetics. Medical equipment for diabetes parients. Copenhagen, USA - Jun 13, 2023Shutterstock

As described by WebMD, Bydureon BCise is an extended-release form of exenatide used for type 2 diabetes management. It's administered once weekly via a 2mg single-dose autoinjector. Like other medications in its class, it works by stimulating insulin production, controlling liver sugar release, and slowing digestion.

What You Need to Know About Victoza (Liraglutide)

Prague,Czech republic-June 27 2024: VICTOZA medication with Liraglutide active substance by Novo Nordisk, used for treatment of diabetes mellitus type 2, weight management, hyperglycemia,injectionShutterstock

According to WebMD, Victoza contains liraglutide and is prescribed for type 2 diabetes management. It's also specifically indicated to lower cardiovascular event risks in diabetic patients with heart disease. The medication functions similarly to other drugs in its class by increasing insulin production, reducing liver sugar release, and slowing digestion. It's available as an 18mg/3mL solution in pre-filled pens.

Daily vs. Weekly Options

Hands,In,Blue,Surgical,Gloves,Holding,Ozempic,Insulin,Injection,PenShutterstock

"In the short term, these medications may be fine," Dr. Risinger notes, "but realize that some of them may need to go back to daily injections instead of once a week." She explains that while they're not as potent as Semaglutide (Ozempic) or Tirzepatide (Mounjaro/Zepbound), they can still be effective.

RELATED:What Happens to Your Body When You Stop Taking Ozempic

Choosing the Right Alternative for Your Condition

Close up of a female doctor filling up an application form while consulting patientShutterstock

For diabetes management, Dr. Risinger is specific: "If you've been using Ozempic for diabetes and you're no longer able to get it, then Victoza is the next best alternative for you, but realize you have to do the injection daily."

For those using Wegovy for weight management, she advises: "Saxenda may be a good fit for you in the interim, but realize once again, this medication needs to be taken once a day."

The key is working with your healthcare provider to find the most appropriate alternative that aligns with your treatment goals and lifestyle needs. While these alternatives might require more frequent dosing, they can help maintain your progress until your preferred medication becomes available again. And if you enjoyed this article, don't miss20 Incredible Ozempic Success Stories of All Time.

Nutrition & Diet

11 Things to Know Before Taking Ozempic

Dr Sophie GP
Copyright Dr Sophie GP/YouTube
Christopher Roback
By Christopher RobackMar 31, 2025
Christopher Roback
Health & Wellness Writer | Author | Exclusive Contributor at Body Network
Christopher Roback is a health and wellness writer and exclusive contributor to Body Network.
See Full Bio
✓Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

We've all been there - trying diet after diet, exercise plan after exercise plan, only to find ourselves struggling to lose weight or keep it off. If you've been wondering about those "miracle" weight loss drugs like Wegovy and Ozempic that celebrities are raving about, you're not alone. Dr. Sophie Newton breaks down exactly how these medications work and what you should consider before jumping on the bandwagon. Read on to discover if these treatments could be the kickstart to your weight loss journey that you've been looking for.

Yes, They Actually Work

"These medications have shown impressive results in clinical trials," Dr. Sophie says in her post. "In randomized double-blind control trials, people using Wegovy lost an average of 12% more body fat compared to those in the placebo group." Dr. Sophie explains that colleagues in the United States report excellent outcomes with patients successfully losing weight and maintaining it while on the medication.

RELATED: 15 Things to Know Before Requesting Ozempic for Weight Loss

The Celebrity Connection

Khloe Kardashian at the Cosmopolitan's 50th Birthday Celebration held at the Ysabel in West Hollywood, USA on October 12, 2015.

Shutterstock

"High-profile individuals like Elon Musk and reportedly Khloe Kardashian have used these medications for weight loss," notes Dr. Sophie. She mentions that this celebrity endorsement has led to the medication being nicknamed "the skinny shot" and has dramatically increased public interest in these treatments.

How These Drugs Actually Work

Valparaiso, IN USA - January 22, 2024: Wegovy semaglutide pens for treatment of chronic obesity, close up​Combining Natural GLP-1 Boosters for Maximum ResultsShutterstock

"These medications belong to a group called GLP-1 analogues," Dr. Sophie explains. "Wegovy contains semaglutide, which essentially makes you feel less hungry and more easily full, so you naturally eat less and lose weight." Dr. Sophie clarifies that the mechanism is straightforward and typically very effective for most patients.

Health Benefits Beyond Weight Loss

Man having chest pain - heart attack, outdoors​Myth 4: Fat Is Bad For Your HeartShutterstock

"When losing weight with these medications, you're also reducing your risk of conditions like type 2 diabetes and heart disease," Dr. Sophie points out. She highlights that the drugs help lower metabolic risk factors, providing substantial health benefits beyond mere cosmetic improvements.

RELATED:20 Possible Ozempic Side Effects

Common Side Effects to Expect

Woman bending over toilet and having a nausea, vomit, vomitting, sick, bathroom

Shutterstock

"Like all medications, these drugs come with potential side effects," warns Dr. Sophie. "Most commonly, patients might experience nausea, vomiting, diarrhea, constipation, bloating, or excess gas." Dr. Sophie notes that these symptoms typically settle as the body adjusts, and treatment usually starts with a lower dose that gradually increases.

Serious Side Effects to Be Aware Of

Endocrinologist examining throat of young woman in clinic. Women with thyroid gland test . Endocrinology, hormones and treatment. Inflammation of the sore throat

Shutterstock

"If you have a personal or family history of thyroid cancer, these medications aren't suitable for you due to a potential link," cautions Dr. Sophie. She adds that in some cases, the medications have been associated with pancreatitis, though most people tolerate the treatment well despite these risks.

Accessibility and Cost Considerations

Montreal, CA - 16 November 2023: Ozempic semaglutide injection pens. Ozempic is a medication for obesity​These Were Game ChangersShutterstock

"While these drugs are approved by NICE on the NHS, they're only available through specialist weight loss centers, which aren't accessible to everyone," Dr. Sophie explains. She points out that many people must pay privately, creating a financial barrier that might prevent some from accessing this treatment option.

RELATED:What Happens to Your Body When You Stop Taking Ozempic

It's Not a Forever Solution

,Plus,Size,Women,Jogging,Obesity,overweight,happy,celebrate,run,running,fat​Creating Sustainable HabitsShutterstock

"You can regain weight after stopping the medication unless you maintain the lifestyle changes you've implemented," Dr. Sophie advises. She recommends thinking of these drugs as a kickstart to healthier habits rather than a permanent solution, emphasizing the importance of continued diet and exercise modifications.

A Comprehensive Approach Is Still Necessary

Healthy food at home. Happy woman is preparing the proper meal in the kitchen.​DinnerShutterstock

"While using these medications, you still need to focus on improving your diet, lifestyle, and increasing physical activity," Dr. Sophie stresses. She reminds patients that the drugs work best as part of a comprehensive approach to weight management that includes all the fundamentals you already know about.

Last Word

ozempic wegovyWegovy vs Ozempic: Pros and Cons for Weight Loss TreatmentShutterstock

If you're considering weight loss medications like Wegovy or Ozempic, remember they're most effective when combined with lifestyle changes. While they can provide an excellent starting point for your weight loss journey, sustainable results require ongoing commitment to healthy habits. Always consult with your healthcare provider to determine if these treatments are appropriate for your specific situation and health history. And if you enjoyed this article, don't miss20 Incredible Ozempic Success Stories of All Time.

Nutrition & Diet

Mom of 4 Lost 55 Pounds on Semaglutide "Now I Finally See Myself in the Mirror"

Karli_Sine11
Copyright karli.sine/Instagram/Shutterstock
Christopher Roback
By Christopher RobackDec 29, 2024
Christopher Roback
Health & Wellness Writer | Author | Exclusive Contributor at Body Network
Christopher Roback is a health and wellness writer and exclusive contributor to Body Network.
See Full Bio
✓Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

Standing in front of the mirror and seeing a stranger stare back – that's how Karli Sine felt after having four boys in quick succession. Between multiple pregnancies and PCOS, this Utah mom watched her weight climb to 195 pounds despite trying everything from keto to crash diets. Then she discovered semaglutide. In just five months, Karli lost 55 pounds and, more importantly, found herself again. Whether you're considering semaglutide or just starting your journey, her candid story reveals what doctors might not tell you about life on a GLP-1.

The Breaking Point: Why Another Diet Wasn't the Answer

"When I met my husband, I had just lost 16 pounds doing keto and weighed 180 at 5'9"," Karli shares in her post. But four pregnancies changed everything. "I had my first baby in 2017, did keto again, and lost 15 pounds. Then, I got pregnant with my second, third, and fourth. I never lost the weight – it just kept piling on."

The struggle became overwhelming. "I started just wearing tents for clothing. There was no other option for me. At least it didn't feel like there was," she recalls. "Even when I would get ready, I didn't feel like I looked like myself. It was a really hard time."

RELATED: 20 Things You Need to Know About Ozempic and Weight Loss

Starting Semaglutide: The First Month Truth

Finding reliable information wasn't easy. "I had heard about it from a friend, but there wasn't really anyone talking about it online," Karli explains. Even her doctor seemed uncertain: "When I asked him, he was kind of like, 'Yeah, I've heard about it, don't know much about it.' It made me not feel very confident."

She started cautiously: "I began with 10 units for two weeks, then 20 units for six weeks," she details. The journey wasn't smooth. "The first week, I felt nothing. Then, the second week, two days after my shot, I got really sick. But it wasn't like pregnancy sickness – I could take a Zofran and the nausea would go away."

The Adjustment Period: What Nobody Tells You

"Week two to week five, I was wildly tired," Karli admits. "It was really hard for me to take care of my kids just because I wanted to sleep all day long." But she persevered, gradually increasing her dose: "I went up slowly - 25, 30, 35, and then 40 for a minute, then hit 50, before starting to go backwards."

The key was finding a sustainable routine. "Semaglutide can slow your gastric system," she explains. "When I would wake up, I would have a protein shake or eggs – something that was going to sustain me. I was drinking water wildly, which isn't like me. I'm a soda girl, but I couldn't even get myself to drink soda while on this."

Beyond the Scale: Unexpected Changes

The medication's impact went far beyond weight loss. "It helped so much with my PCOS," Karli shares. "My period ended up different, but better. A lot of my inflammation went down in my joints." Even her habits changed: "My online shopping plummeted. I just had no desire. There are studies showing that once people start semaglutide, some of their bad habits kind of go away."

RELATED:20 Possible Ozempic Side Effects

Finding Your Support System

The journey highlighted the importance of community. "In a weight loss journey, it's hard to find someone you're comfortable with, someone who can hold you accountable," Karli reflects. "This scenario with medication is different – it's more of an adjustment period."

She encourages openness: "There's a whole group of people who are like, 'Oh, I don't really want to tell people that I'm on it.' You don't have to tell anyone, but telling people helped me with my support."

The Maintenance Strategy That Works

After reaching 139 pounds – surpassing her goal of 140 – Karli focused on sustainability. "I went from weekly to biweekly, and then after a few months, to monthly," she explains. "While I don't want to be on it forever, it's really changed my life. I'm at a super tiny dose right now, and monthly has been great for me."

Looking Ahead: The Next Chapter

Success with semaglutide opened new possibilities. "Now for 2024, I'm onto a whole new journey of building muscle," Karli shares. "Finally, I feel that I'm at the capacity to take this on."

The transformation went deeper than physical changes. "Looking in the mirror and saying, 'That's how I have viewed myself my whole life, but it's not what other people were seeing' – that's been the best part," she reflects. "I know that my body and image isn't what's most important, but it's really nice to feel that it reflects what's in my head. I've gained so much more confidence back and feel like a different person."

RELATED:What Happens to Your Body When You Stop Taking Ozempic

Final Advice

Her final advice remains encouraging: "Whether the decision is to do it or not, do what's best for you. Hopefully, this will make you feel more like you. I'm proud of you." And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.

Nutrition & Diet

10 Things to Know Before Taking a GLP-1 Drug

Stephanie Snow stephsnow np
Copyright stephsnow np/Instagram
Leah Groth
By Leah GrothJan 24, 2025
Leah Groth
Writer, Editor, and Content Creator
Leah Groth has decades of experience covering all things health, wellness and fitness related.
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Are you thinking about taking Ozempic or another weight loss drug to help you drop unwanted pounds? You should know several things before getting a jab, says one expert. Stephanie Snow is a Weight Loss Provider, Nurse Practitioner, and Obesity Medicine specialist who has used weight loss drugs herself. In a few new social media posts, she reveals everything you should know before getting on them. “I’ve been on this journey too, so I know it’s not easy. As a nurse practitioner and a GLP-1 user, here are five things I wish I could tell my past self,” she writes.

You Deserve to Feel Good in Your Body

Her first truth? You deserve to feel good in your body. “Taking steps to care for yourself isn’t selfish. You’re allowed to prioritize your health and well-being,” she says.

Progress Won’t Always Be Linear

Next, she reminds that progress won’t always be linear, so don’t get hyper-focused on it. “Some days will be easier than others, and that’s okay. Be patient and compassionate with yourself through every step,” she writes.

Listen to Your Body, Not Just the Numbers

Don’t let the scale dictate your success. Listen to your body, not just the numbers, she says. “It’s tempting to focus on scales and calories, but how you feel physically and emotionally matters more,” she writes.

RELATED:20 Things You Need to Know About Ozempic and Weight Loss

You’re Not Taking the Easy Way Out

No matter what anyone says, going on weight loss drugs doesn’t mean you are taking the easy way out. “This journey requires courage, commitment, and self-love. GLP-1 is just one of many tools you’re using to take control of your health,” she says.

Celebrate Small Wins

Don’t just celebrate milestones, celebrate small wins. “Every step forward, no matter how small, is a victory. Take pride in the progress you’re making, one day at a time,” she writes.

RELATED:20 Possible Ozempic Side Effects

Fullness Comes Fast

In another post, she reveals five more things she wishes she knew before starting weight loss drugs. The first? Fullness comes fast. “You’ll feel full quicker than expected. Adjust your portions and trust your body’s signals,” she writes.

Hydration is Essential

Next, make sure to hydrate. “Staying hydrated aids digestion and helps prevent nausea. Keep that water bottle handy!” she recommends.

RELATED:What Happens to Your Body When You Stop Taking Ozempic

Protein is Your Pal

Ensure you are eating enough protein to keep you feeling and help build muscle. “High-protein meals and snacks boost energy and keep you satisfied between meals,” she writes.

Embrace Imperfection

Another thing you should do? Embrace Imperfection. “Not every day will be perfect, and that’s okay. Progress isn’t linear; keep going even when it’s tough,” she says.

Patience Pays Off

Last but not least, remember that patience pays off. “Sustainable weight loss takes time. Be patient with yourself and stay consistent,” she writes. And if you enjoyed this article, don't miss20 Incredible Ozempic Success Stories of All Time.

Nutrition & Diet

She Lost 30 Pounds While Eating These Popular Foods

Denise Hamdan denisehamdan
I Lost 30 Pounds While Eating These High-Protein Foods
Copyright denisehamdan/TikTok
Leah Suzanne
By Leah SuzanneMay 12, 2025
Leah Suzanne
Freelance Writer/Editor
See Full Bio
✓Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

Denise Hamdan (@denisehamdan) is a food and fitness influencer on TikTok who regularly shares her tricks and tips on weight loss with her 71,000 followers. Hamdan lost a whopping 30 pounds by following a healthy diet and exercising. In a recent clip, she reveals her diet. “Hey y'all, here's everything I ate in one day to stay lean as someone who lost 30 pounds,” she says, revealing that she eats 1829 calories and 147 g of protein per day. Body Network’s Resident RDN, The Diet Diva, Tara Collingwood, MS, RDN, CSSD, LD/N, ACSM-CPT, a Board Certified Sports Dietitian, co-author of the Flat Belly Cookbook for Dummies, also weighs in.

Breakfast

“I started my morning with my breakfast cocktail of oxygen and creatine. I just added the products to my showcase. So go check them out. I have my cocktail with Greek yogurt with strawberries and blueberries and a drizzle of granola,” she says. The total calories equal 157 and 14 g protein.

Lunch

“I'm in this phase where I eat nearly the same thing every day, and that's been scrambled eggs with cheese and spinach and some turkey bacon on the side,” she says about her lunch. “And honestly, I'm not complaining because it hits every time. Her total calories are 562 and 52 g protein.

Green Smoothie

Sometimes she will have a smoothie instead. “I made a cute little green smoothie and it was a little messy, but it was good regardless,” she says.

Pre-Workout Snack

“Later, for a pre-workout snack, I made some cute little tuna crackers with the green onion and bell pepper,” she says about the snack totaling 430 calories and 28 g protein.

OxyShred and Pre-Workout

“Then I got to the gym and made my OxyShred and pre-workout combo before hitting cardio and abs,” she continued. “It had me sweating.”

Protein Bar

“Right after my workout I had my favorite dark chocolate pretzel protein bar,” she continued.

Dinner

“And finally for dinner I made this super easy teriyaki chicken bowl over brown rice,” she said, adding that the 560 calorie and 52 gram protein meal is “so delicious and the macros forward are amazing.”

Dessert

“Lastly, for dessert, I had some chocolate 'cause I cannot end the day without a little sweet treat,” she said about the 120 calorie sweet treat.

RDN Weighs in

tara collingwoodI'm a Nutritionist and These 9 High-Protein Snacks Keep My Clients Full While Losing 50 Pounds

Copyright Tara Collingwood

“1800-1900 calories seems like a good amount for her, but I don’t know her exact age, height, weight, or exercise level,” says Collingwood. “147 grams of protein is probably more than she needs, but it is not dangerously high.”

Try Eating More Vegetables, Expert Says

“I see a little bit of fruit on the yogurt and a tiny bit of spinach in eggs and peppers in tuna but overall not much veggie intake (green smoothie was green powder and not real whole veggies) which is proven with only 16 grams of fiber for her overall day,” Collingwood continues. “I would recommend increasing veggies to aim for 25 grams of fiber each day.” She also likes how often she is eating with the meals and snacks in between. “I do worry about the OxyShred. I couldn’t find on their website anywhere exactly how much caffeine is in it and having it later in the day could definitely impact sleep since caffeine has a 5 hour half-life,” she points out.

💪🔥Body Booster: How much protein should you consume per day? Aim for 0.8 to one gram per pound of bodyweight. And if you enjoyed this article, take advantage of these 15 Quick Ways to Lose Body Fat Percentage in a Week

Nutrition & Diet

20 Things to Avoid While on Ozempic

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20 Things to Avoid While on Ozempic
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Leah Suzanne
By Leah SuzanneMay 12, 2025
Leah Suzanne
Freelance Writer/Editor
See Full Bio
✓Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

Ozempic can be highly effective for weight loss, but there are definitely some unpleasant side effects to contend with, as the makers of the drug, Novo Nordisk, warn about. Nausea, constipation, and stomach pain are common, but avoiding certain foods and behaviors can make a difference. Here are 20 things to avoid while on Ozempic, to make the most of the medication and encourage healthy weight loss.

Too Much Sugar

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Added sugars, and sugary sodas, can spike blood sugar. Novo Nordisk, the maker of Ozempic and Wegovy, recommends that people avoid sugary foods while on the drug. “If you are taking medication to lower your sugar levels, it is advisable to avoid excess sugar consumption,” Dr. Dina Peralta-Reich, MD, FAAP, FOMA, tells Parade. “Failure to watch what you eat and keep your sugar levels elevated may prevent you from seeing the intended results of the medication,” she shares.”

Ultra-Processed Foods

Pop,Tarts,Toaster,Pastry,processed,food,sugar​2. Processed FoodsShutterstock

Ultra-processed foods can make side effects of Ozempic worse. “This medication slows down gastric emptying and the dense food will move much slower through your intestines, which can make you feel sick [and experience] nausea, vomiting, reflux and abdominal pain,” says Dr. Peralta-Reich. “Someone may not see the results they're looking for either.”

High-Fat Foods

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Foods high in saturated and trans fats can make side effects of Ozempic worse. Some people complain of diarrhea and stomach pains. “I’ve seen an almost dumping syndrome-like response in people taking GLP-1s when they eat simple carbohydrates and high-fat foods,” Dr. Shauna Levy, a specialist in obesity medicine and medical director of the Tulane Bariatric and Weight Loss Center in New Orleans, tells TODAY.

Sitting All Day

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Staying active is important while on Ozempic. Regular exercise is not only important for health, it can prevent muscle loss. The goal should be fat loss, and getting strong.

Not Hydrating

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Don’t forget to drink your water and stay hydrated. Drinking water can help with side effects of Ozempic, especially nausea. Ozempic.com recommends drinking clear or ice-cold drinks to combat any nausea and discomfort.

Too Much Alcohol

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Avoid alcohol on Ozempic, experts advice. “One, it’s just empty calories. Two, it tends to make people make decisions that they otherwise might not make,” says Dr. Levy. “It could increase hunger, and the whole point of GLP-1s, or at least one of the points, is to decrease hunger. So it sort of negates their purpose.”

Be Mindful of Portions

Healthy diet plan for weight loss, daily ready meal menu. Close up Woman weighing lunch box cooked in advance,ready to eat on kitchen scale. scales, weighShutterstock

Ozempic keeps food in the stomach longer, so bigger portions can cause discomfort. “Understanding that overall portions are smaller on these medications, we want to optimize nutritional intake and consume the ‘best’ calories available,” obesity medicine physician Dr. Christopher McGowan tells TODAY. “The focus should be on lean protein, healthy fruits and vegetables, adequate fiber and adequate fluid intake.”

Be Mindful of Coffee

Man in the kitchen pouring a mug of hot filtered coffee from a glass pot. Having breakfast in the morningShutterstock

“Overall, coffee is perfectly fine to consume, but for some individuals can lead to stomach irritation,” says Dr. McGowan. “Therefore, I recommend drinking coffee in moderation, such as one to two cups a day. Patients should also be mindful of calorie-dense additives, like cream and sugar.”

Don’t Skip Meals

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It’s easy to skip meals when on Ozempic, but make sure you’re getting enough nutrition. Some people have even become malnourished as a result of not eating. “It’s never healthy to not eat,” Dr. Hwang said. Dr. Janice Jin Hwang, the division chief of endocrinology and metabolism at the University of North Carolina School of Medicine tells the New York Times.

Don’t Consider It a Quick Fix

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Ozempic should be part of a long-term health plan. “It’s important to note that if you start taking either of these drugs for weight loss, your body may get used to it, establishing a new normal,” says UC Davis Health. This can cause your weight to plateau. Research has shown that if you stop taking Ozempic (or Wegovy), it's likely that you will gain back the weight you lost.”

Same Unhealthy Lifestyle

Bartender pours alcoholic drink into small glasses on bar​Don’t Drink as Much AlcoholShutterstock

Don’t continue an unhealthy diet and assume it’s ok because of Ozempic. “You can likely lose weight on semaglutide medications without changing your diet and activity behaviors, but these lifestyle changes will make the treatment more effective,” Richard Siegel, MD, tells the Friedman School of Nutrition Science and Policy. “Also, we don’t know if weight loss will have the same health benefits if one does not change their behaviors.”

Protect Your Health

Montreal, CA - 16 November 2023: Ozempic semaglutide injection pens. Ozempic is a medication for obesityMost Women on GLP-1s Are Making a Few Common MistakesShutterstock

Some doctors warn that taking Ozempic can make people complacent about their health. “It is important to remember that obesity is heterogenous, chronic and complex,” Vijaya Surampudi, MD, physician nutrition specialist and assistant director of the UCLA Weight Management Program (RFO), tells UCLA Health. “There is no cure for obesity. It requires lifelong treatment that’s not one size fits all.”

Carbonated Beverages

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Ozempic slows down digestion, keeping food in your stomach for longer. This causes a feeling of fullness and some unpleasant side effects for some people like belching. Stick to still water as carbonated beverages can make stomach issues worse.

Long-Term Goals

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If you plan on only taking Ozempic or Wegovy for a short while, it’s likely your weight will come back on. “In one trial of Wegovy, people regained about two-thirds of the weight lost within a year of stopping the drug,” Dr. Siegel explains. “Lifestyle changes can help maintain weight loss, but it’s unusual to maintain all weight loss once you stop any weight loss medication.”

Refined Carbohydrates

Poached,Egg,Toast,breakfast​Eat BreakfastShutterstock

Refined carbohydrates tend to spike blood sugar, which is exactly what Ozempic is meant to treat. You don’t have to cut these foods out entirely, but be aware it makes it harder for Ozempic to do its job. “Foods like white bread, white rice, crackers, or even cereals may seem like better choices than foods with added sugar, but refined carbohydrates still metabolize as glucose in the body,” Christine Fallabel, MPH, tells Diabetes Strong.

Watch Out For High Fiber

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While many green vegetables are low GI, be careful about the fiber. “If you’re not used to eating a lot of vegetables, you may experience side effects such as bloating and gas, until your body has acclimated to eating a more fiber-filled diet,” Fallabel says.

Junk Food

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Junk food—which you should be avoiding either way for weight loss purposes—often contains high levels of sodium. “Ultra-processed foods are high in sodium, saturated fats and added sugars, which contribute to a range of health problems,” Elizabeth Ko, MD, and Eve Glazier, MD, tell UCLA Health. These include an increased risk of Type 2 diabetes, cardiovascular disease, lowered immune response, certain cancers, dementia and early death.”

Spicy Foods

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Ozempic can cause acid reflux due to slow digestion. Spicy foods can make acid reflux worse, experts warn. However, if acid reflux is not an issue, people can probably enjoy spicy foods if they wish.

Always See a Medical Professional

GDANSK, POLAND - MAY 2022: obese fat man preparing Semaglutide Ozempic injection control blood sugar levels​The Drugs Mimic the GLP-1 Hormone Naturally Produced by the BodyShutterstock

Ozempic should only be prescribed by a medical professional. “Typically, I prescribe Ozempic for diabetes and have more often prescribed Wegovy for weight loss,” endocrinologist Alyssa Dominguez, MD, tells Keck Medicine. “I have used Ozempic, sometimes, off-label for weight loss, though getting insurance approval for that can be challenging.”

Fried Foods

French fries in hot fat in a deep fryer​3. Deep-Fried ItemsShutterstock

Fried, greasy foods can make Ozempic stomach issues worse. “Foods high in fat can make digestive side effects worse. Since food hangs around longer in the stomach, it has more time to cause problems,” Sarah Bullard, MS, RD, LD, tells Signos. “Some studies have shown that consuming too much fat can increase symptoms of fullness, nausea, and bloating in individuals with digestive issues and heartburn. Reducing fat intake resolved symptoms.”

💪🔥Body Booster: A whole foods Mediterranean diet is ideal while taking Ozempic.

Fitness & Workouts

Sophie van Oostenbrugge Shares Her Routine

Sophie van Oostenbrugg gainsbybrains
Copyright gainsbybrains/Instagram/Shutterstock
Leah Suzanne
By Leah SuzanneMay 11, 2025
Leah Suzanne
Freelance Writer/Editor
See Full Bio
✓Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

Do you want to get your glutes sculpted for summer? Sophie van Oostenbrugg is a fitness trainer and the founder of the Gains with Brains app. She regularly shares workouts with her 2.4 million Instagram followers on how to burn fat and build muscle. “I grew up hearing that women should be as small as possible. That’s why I loved being able to share my bulking journey on social. I’ve done 2 bulks so far.. and I was thinking about starting and sharing a 3rd one,” she wrote in a recent post. She also revealed her “medium leg day” workout, which will help you tone up fast.

She Does Multiple Leg Days a Week

“I have good news today..it’s a medium leg day!!!🫣🤭sooo I split my leg workouts & currently have lighter, medium and heavier days. this helps me with recovery, train through a variety of rep ranges and make it more enjoyable,” she explains in the post.

She Does 8 to 12 Reps of Each Exercise

In the video she explains that she has “multiple leg days per week.” She goes onto reveal all of the exercises she does with “rep ranges from 8 to 12.”

RDLS

“I started with RDLs, four sets of eight,” Sophie reveals. To do Romanian deadlifts, start with both legs pressed evenly on the floor. “Slightly bend knees while bending over,” says The Body Network’s Resident RDN, The Diet Diva, Tara Collingwood, MS, RDN, CSSD, LD/N, ACSM-CPT, a Board Certified Sports Dietitian. “Keep your arms pointing down toward the floor and lower with you almost touching the floor. Keep hips and shoulders square facing forward throughout the exercise. Return to standing.” She suggests repeating 10 to 12 times with the right leg and repeating on the left side. “Progression includes holding a weight in the arm pointing toward the floor,” she adds.

Sumo Squat with Kettlebell

“Then I moved on to a sumo squat with kettlebell. You know the deal, form over everything, so go slow and control the weight,” she says. Sumo squats are similar to regular squats, only you point your toes outward.

Glute Bridges

“Then I did glute bridges,” Sophie continues. You can do glute bridges with or without weights.

Cable Step Up

Next up? Cable step ups, using an exercise block. “These are great as they help with balance and therefore they're easier to overload,” she says.

Seated Leg Curl

She sits down at a machine. “Then I did a seated leg curl,” she says.

Core Exercise

“I finished with some core exercises,” Sophie concludes. “I want to get my core as strong as humanly possible so I can keep recording more intense ab workouts.”

💪🔥Body Booster: Try splitting up your workouts into light, medium, and intense days to allow your body ample time needed to recover.

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