Rosie O'Donnell Lost 50 Pounds for Diabetes and Here's What She Eats in a Day at 63
Rosie O'Donnell made several essential lifestyle tweaks to help manage her diabetes. In the process, the comedian lost a significant amount of weight—50 pounds. Along with adding more movement to her days and taking Mounjaro, here's everything we know about O'Donnell's weight-loss journey—and how she optimized her diet.
She Took Mounjarno To Help Manage Her Diabetes
The celeb took popular weight-loss medication Mounjaro to help manage her diabetes.
O'Donnell previously shared on Instagram, "I can't believe this is me now," and, "I've lost more weight here. I am on Mounjaro for my diabetes and one of the side effects is you lose weight" (via E! News).
She Started Taking the Prescription Drug in 2022
O'Donnell kickstarted this recent wellness journey in late 2022, when she began taking Mounjaro, according to E! News.
In February 2024, the comedian shared on Instagram, "One year on mounjaro #healthy #life. RED SHIRT NOW – BLUE A YEAR AGO."
She Dropped Roughly One to Two Pounds Each Month
O'Donnell shared exclusively with Page Six that, while taking Mounjaro, she lost an estimated one to two pounds each month.
She Said She Couldn't See Herself "In This New Smaller Body"
In August 2025, O'Donnell shared on Instagram that she went shopping to find a cozy outfit for her long flight to Australia. In the photo, the 63-year-old comedian is wearing a black workout set, and wrote, "was undecided as [I can't] see myself in this new smaller body" (via E! News).
She Always Struggled With a "Weight Issue"
The Emmy Award-winning talk show host revealed she's always battled with a "weight issue." O'Donnell explained on TikTok, "I'm one of those people who's always had a weight issue and now that I'm a size large, instead of an XL or a 2XL, I find it shocking … I've been wearing elastic-waist pants for a very long time" (via E! News).
She Only Drinks Water
Staying hydrated is key in any successful wellness journey. O'Donnell clearly understands the importance of drinking plenty of water—in fact, it's the only beverage she drinks!
"I stopped drinking anything except water. I really stopped drinking five or six Diet Cokes a day. All I drink is water now, and I'm not eating sugar as much as I can," O'Donnell shared in a 2023 TikTok (via E! News).
She Tried the "Tiffany Plate" Trend on TikTok
When it comes to O'Donnell's diet, the celeb took part in the "Tiffany plate" trend, which was created by weight-loss influencer Tiffany Magee.
"This is my first Tiffany platter. It's on TikTok and everyone makes their own little healthy food thing and then they eat it during the day. So mine has Babybel reduced fat cheese, eggs, sausage, mushrooms, olives, a little bit of chicken breast, some vegetables and some fruit," O'Donnell shared in a May 23, 2025 clip (via E! News).
She Had a Chef
The celeb revealed on TikTok in March 2025 that having a personal chef for more than two years helped her lose weight (via PEOPLE).
"I've lost more weight. I am on Mounjaro for my diabetes and one of the side effects is you lose weight," she shared. "But it's also because I had a chef for over two years in Los Angeles and I don't have a chef now. It's me cooking for Clay and me."
She Stopped Eating as Much Sugar
Other tweaks O'Donnell made to her diet while taking Mounjaro? She revealed she's "not eating sugar as much as I can" (via PEOPLE). In addition, the comedian noted her appetite "has decreased significantly," adding, "It's probably the meds. And I'm trying to move more. So, all those things combined, that's what it is."
For more weight-loss success stories, check out Ricki Lake Lost 35 Pounds and These 6 Habits Helped Her Transform Her Body.
