5 Ozempic Side Effects That Catch Most Users Off Guard After Losing 50+ Pounds

Taking prescription meds is never something to approach lightly. Every single drug has its own risks and warnings—some are minor and some are more serious. The extremely popular weight-loss drug Ozempic is no exception. In fact, there are five lesser-known side effects that can catch users off guard—especially after achieving a 50-pound weight loss. Once you learn what they are, you can determine whether or not this fast-growing weight-loss trend is the right path for you.

Ozempic was originally formulated to help patients control type-2 diabetes. In recent years, however, Ozempic has become one of the most popular solutions for weight loss. For many individuals, it's been completely life-changing. But prior to taking any medication—especially a drug as strong as Ozempic—it's essential to be mindful of everything involved and potential side effects.

According to Dr. Anthony Puopolo, President, LifeMD Affiliated P.C.s., here are some side effects that tend to surprise patients the most after substantial weight loss on a GLP-1.

"When someone loses a significant amount of weight, the body moves through a series of shifts as it adjusts to its new state. During this time, some people may notice symptoms related to the gallbladder, pancreas, or kidneys," explains Dr. Puopolo. "These shifts are often influenced by dehydration, changes in how the body processes fat, and normal metabolic transitions that occur with weight loss. More uncommonly, these factors can contribute to issues such as gallstone formation, temporary kidney strain, or pancreatitis."

Drinking plenty of water, maintaining a balanced diet, and regularly checking in with your healthcare provider can help minimize risks and promote a smoother transition.

5 Ozempic Side Effects After Losing 50+ Pounds

1. Mood changes: Taking GLP-1s can majorly impact mental wellness, especially when combined with decreased food consumption and the added pressure to avoid weight gain in the future.
2. Hair loss: "This may occur due to shifts in how the body utilizes protein. Increasing protein intake—and focusing on balanced nutrition overall—may help strengthen hair over time," Dr. Puopolo tells us.
3. Fatigue: Fatigue occurs as your body adapts to changing appetite signals and decreased calorie intake. "These shifts can temporarily affect energy levels while your system finds its balance," Dr. Puopolo says.
4. Loss of muscle mass: The loss of lean muscle can occur with insufficient protein consumption. That said, emphasizing a protein-packed diet and increased resistance training can help you maintain and build muscle.
5. Loose skin. "Some people may notice changes in areas where fat tends to reduce more quickly, resulting in skin that appears looser or less full," Dr. Puopolo explains. "These areas often include the hands, feet, face, and neck. Significant fat loss can also make certain features appear more hollow or can lead to mild sagging. Keep in mind that some of these changes may improve over time."

If you're wondering how to optimize your diet while taking a GLP-1, check out I Lost 60 Pounds on Wegovy After 45 and These 3 Protein Swaps Saved My Muscle Mass.