Amy Schumer Lost 50 Pounds After Her Diagnosis and Here's the Medical Condition She Says Almost Killed Her
Amy Schumer has brought endless laughs to fans. From Kinda Pregnant to I Feel Pretty to Trainwreck, and so much more, Schumer has become a very familiar and beloved face on the big screen. The actress and comedian revealed she lost 50 pounds and feels incredibly "grateful to be strong and healthy." We're here with the medical condition that completely changed Schumer's life.
She Was Diagnosed With Cushing Syndrome
The actress revealed in 2024 that she was diagnosed with Cushing syndrome, according to E! News. This condition—also known as hypercortisolism—occurs when there's excess cortisol in the body, which can be caused by certain medications or simply because your body produces the hormone in surplus.
She Lost 50 Pounds "To Survive"
Schumer reportedly opened up about her weight loss on Instagram, writing in a December 2, 2025, post, "I didn't lose 30lbs, I lost 50. Not to look hot which does feel fun and temporary. I did it to survive. I had a disease that makes your face extremely puffy and can kill you but the internet caught it and that disease has cleared" (via E! News).
She Feels Healthier
In her December 2025 post, Schumer noted that, overall, she felt much healthier.
"I have been working to be pain free and I finally am. My endometriosis is better. My back is healing. I no longer have Cushing syndrome so my face went back to normal. I am grateful to be strong and healthy, especially for my son," the celeb revealed.
She Uses Mounjaro
The actress has been incredibly open about using Mounjaro, previously noting she had a "really good experience" with the prescription weight-loss medication (via TODAY.com).
She Works Out Hard
Schumer's workout routine isn't for the faint of heart. She's worked with a boxing trainer and top celeb trainer Harley Pasternak, who called the comedian "naturally an athlete."
Pasternak also shared, "She played sports at a high level through high school and college, and was an aerobics instructor. So she's very coordinated, and easy to push in the gym" (via TODAY.com).
For more weight-loss success stories, check out Ricki Lake Lost 35 Pounds and These 6 Habits Helped Her Transform Her Body.
