15 Effective Ozempic Alternatives for Sustainable Weight Loss

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        15 Ozempic Alternatives for Effective Weight Loss
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By Ferozan MastMay 15, 2024
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Ferozan Mast is a science, health and wellness writer with a passion for making science and research-backed information accessible to a general audience. 
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By Ferozan MastMay 15, 2024
Ferozan Mast
Writer
Ferozan Mast is a science, health and wellness writer with a passion for making science and research-backed information accessible to a general audience. 
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        15 Things to Know Before Getting Ozempic for Weight Loss
    

        13 Weight Loss Alternatives When Ozempic Isn't Available That Experts Swear By
    
Ozempic is the weight loss drug du jour right now—but it’s certainly not the only effective medication available. For some people, medication may not even be needed. “I’m glad we now have potent medications for obesity, but these drugs are not a replacement for healthy lifestyle changes. To be healthy, people need to make sure they exercise most days of the week and consistently choose healthy foods,” Dr. Cecilia Low Wang tells UC Health. Here are 15 food, drug, and diet alternatives to Ozempic to encourage effective weight loss.
Wegovy
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Unlike Ozempic, Wegovy is actually prescribed as a weight loss drug, not a diabetes medication. Like Ozempic, it is a semaglutide drug and is administered as a subcutaneous injection using a single-use, prefilled injection pen.
“Wegovy acts on areas of the brain which are involved in regulating your appetite,” Dr. Mihir Sanghvi tells the British Heart Foundation. “It increases feelings of fullness, reduces feelings of hunger and reduces the preference for high-fat foods. It also reduces blood sugar by promoting the release of insulin when blood sugar levels are high.”
Saxenda
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Saxenda (liraglutide) is a weight loss injection that helps curb appetite. “Liraglutide promotes weight loss,” says the Cleveland Clinic. “It may also be used to maintain weight loss. It works by decreasing appetite. Changes to diet and exercise are often combined with this medication.”
RELATED: 20 Incredible Ozempic Success Stories of All Time
Mounjaro
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Mounjaro is an injectable medication designed for people with type 2 diabetes. “It suppresses appetite and makes you feel more full. It changes the rate at which your stomach empties,” Dr. Cecilia Low Wang tells UC Health.
Zepbound
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“Zepbound is the brand name for the drug tirzepatide when doctors prescribe it for weight loss,” Dr. Low Wang tells UC Health. “Mounjaro is the name of the medication used to treat diabetes. Both Zepbound and Mounjaro are brand names for the generic drug, tirzepatide.”
Metformin
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Metformin is a type 2 diabetes drug that lowers blood sugar and insulin levels. “Metformin lowers your blood sugar levels by improving the way your body handles insulin,” says the NHS. “It's usually prescribed for diabetes when diet and exercise alone have not been enough to control your blood sugar levels.”
RELATED: 20 Things You Need to Know About Ozempic and Weight Loss
Rybelsus
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Rybelsus (oral semaglutide) is a GLP-1 pill that helps lower blood sugar levels for type 2 diabetics. Rybelsus is effective as a weight loss drug due to the effect it has on appetite, encouraging “fullness” and slowing down digestion.
Trulicity
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Trulicity (dulaglutide) is another GLP-1 receptor agonist. “Trulicity is prescribed when diet and exercise have failed to bring blood glucose levels under control,” according to Diabetes UK. “It may also be prescribed instead of metformin, if metformin is unsuitable for you.”
Alli
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Alli (orlistat) is an over-the-counter weight loss drug that works by stopping dietary fat from being absorbed. “Lipase, an enzyme found in the digestive tract, helps break down dietary fat into smaller parts, so it can be used or stored for energy,” says the Mayo Clinic. “Orlistat blocks the work of lipase. When you take the drug with a meal, about 25% of the fat you eat isn't broken down. The fat is passed through bowel movements.”
RELATED:20 Possible Ozempic Side Effects
Januvia
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Januvia (sitagliptin) is a type 2 diabetes medication that works by lowering blood sugar levels.  “Sitagliptin is prescribed to people with type 2 diabetes, and is usually taken alongside a healthy diet and regular, appropriate exercise to help control diabetes,” says Diabetes UK.
Flaxseed For Fullness
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If prescription or over-the-counter medication is not a choice or an option, certain foods—like flaxseed—are not only healthy but can help encourage fullness. Look for foods high in fiber and protein. “Flaxseed's health benefits come from the fact that it's high in fiber and omega-3 fatty acids, as well as phytochemicals called lignans,”  Katherine Zeratsky, R.D., L.D. tells the Mayo Clinic.
Vegetable Soup
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Soups are filling and tend to be low-calorie. “Binding water into foods slows down gastric emptying, which means your stomach stays fuller for longer,” Barbara Rolls, professor of nutritional sciences at Pennsylvania State University and author of the ‘Ultimate Volumetrics Diet’ tells CNN. “The most effective way to reduce calories is to bulk up food with water. You get lots of volume without calories.”
RELATED:5 Foods That Maximize Weight Loss on GLP-1 Medicines, According to Coach
Whole Grains
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“Whole grains are the best option because they're higher in fiber and other important nutrients,” says the Mayo Clinic. “Emphasize whole grains by simply choosing whole-grain options instead of refined grains, including foods made with sugar or white flour.”
Eat Your Calories
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Enjoy high-fiber fruit instead of drinking it. "I like to use the example of eating a 100-calorie orange versus drinking 100 calories of orange juice," dietitian Kylie Arrindell tells Houston Methodist. "You're going to feel full or more satisfied for longer after eating the orange, and you're going to get hungry pretty quickly after drinking the juice."
Broccoli
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Broccoli is a filling, low-calorie food. “Broccoli is a member of the cruciferous vegetable family,” says UnityPoint Health. “It's known for its high water and fiber content, which is a great combination to help you feel full.”
RELATED:What Happens to Your Body When You Stop Taking Ozempic
Lots of Protein
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High-protein foods are ideal for appetite suppression. "Protein is the macronutrient that will likely leave you feeling more sated,” Arrindell tells Houston Methodist. “But fiber-rich carbohydrates — whole grains, beans, lentils, oatmeal, raspberries and even some vegetables like collard greens, kale and artichokes — are a close second.”
💪🔥Body Booster: Always talk to your doctor before taking any new drug or medication.
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        9 Key Differences Between Ozempic and Other GLP-1 Meds for Weight Loss
    

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By Leah GrothJun 26, 2024
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Ozempic is the buzziest drug in the weight loss world. However, it isn’t the only GLP-1 drug people are using to lose weight fast. Before you try and get a prescription, there are a lot of things you need to know about the drug, including how it works and also how it compares to similar treatments on the market. Here are ten key differences between Ozempic and other GLP-1 meds for weight loss, according to triple-board-certified plastic surgeon Leo Lapuerta, MD, The Plastic Surgery Institute of Southeast Texas.
Ozempic Isn’t Even Approved for General Weight Loss
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While Ozempic is probably the most well-known GLP-1, it isn’t technically even approved for general weight loss. “It is for the control of Type 2 diabetes,” Dr. Lapuerta reveals.
Most Weight Loss Drugs Aren’t Approved for Weight Loss
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In fact, most drugs being used for weight loss weren’t even intended for that purpose. “Most of the GLP-1 drugs like Rybelsus, Victoza, Trulicity, and Byetta are intended for the treatment of Type 2 diabetes with beneficial side effects that include weight loss,” explains Dr. Lapuerta.
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Some GLP-1s Offer Heart and Kidney Benefits
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There are other benefits to taking weight loss drugs. “Ozempic, Victoza, and Trulicity all have benefits for the heart and kidneys in addition to control of Type 2 diabetes,” says Dr. Lapuerta.
One Weight Loss Drug Is Injected Daily, Most of Them Are Weekly
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Most of the GLP-1s, including Ozempic, require a weekly injection. However, “Victoza is unique because it is injected daily rather than weekly,” says Dr. Lapuerta.
One Is Available in Oral Format
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And not all of them require a needle. “Rybelsus is the only GLP-1 that is available in oral format as all the other options are by injection only,” says Dr. Lapuerta.
RELATED:What Happens to Your Body When You Stop Taking Ozempic
Some of Them Are Approved for Weight Loss and Weight Management
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Ironically, while the most well-known of the bunch isn’t even approved for weight loss, the majority of the others are. “Wegovy, Saxenda, and Mounjaro (Tirzepatide) are GLP-1 agonists intended for weight loss and weight management rather than the treatment of Type 2 diabetes,” says Lapuerta.
Some Are More Effective Than Others
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According to Dr. Lapuerta, results vary by brand. “Wegovy typically produces 2 to 3 times the percent weight loss as Saxenda,” he maintains.
Only One of Them Includes GIP
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Mounjaro (Tirzepatide) has an edge over the competition. “It is the first GLP-1 to also include GIP, glucose-dependent insulinotropic polypeptide (GIP), another gut hormone agonist that provides better longer-term control of blood sugar as indicated by better reductions in Hemoglobin A1C levels,” says Dr. Lapuerta.
RELATED:20 Things to Avoid While on Ozempic
Some Medications Have Two Names
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Don’t let names deceive you. “Zepbound is the FDA-approved version of Mounjaro specifically for weight loss,” says Dr. Lapuerta.
Keep Reading About Ozempic
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Keep educating yourself about Ozempic. Here are 15 things you should know before getting Ozempic for weight loss. And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.

        
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By Leah GrothMay 12, 2024
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Are you thinking about using Ozempic or another weight loss drug? Before you schedule an appointment with an MD or telemedicine doctor, educating yourself about the drug will give you a better idea of whether or not it’s worth it. Here is everything you need to know about Ozempic—how it works and its benefits for weight loss, how much it costs, and the potential side effects.
How Ozempic Works
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How exactly do weight loss drugs help you lose weight? “Ozempic enhances the release and action of insulin throughout the body, which helps with fat loss,” explains Dr. Sue Decotiis, MD, NYC weight-loss doctor.
Ozempic Shuts Down Your Appetite, and You Feel Full Faster
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“Weight loss drugs also have a tremendous effect on satiety, shutting down appetite so the patient feels very full after eating much less food,” she explains. “Ozempic acts on receptors in the gut and brain that regulate appetite.”
It Also Resets Your Rate for Fat Burning
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Ozempic also targets the centers in the brain that resets a person’s set rate for fat, Dr. Decotiis says. “When your set rate is higher for fat, you tend to hold more weight. When people go on Ozempic it resets the amount of weight that your body wants to hold onto.”
It Improves Insulin Function
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The main way Ozempic works is changing the way insulin works, explains Dr. Decotiis. “When insulin works well, you can burn fat, when it doesn’t you gain weight,” she says.
It Helps Regulate Hormones
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“It helps regulate people’s hormones that have changed due to aging, stress, etc., so that they can lose weight,” she continues. “When people age their hormones change and it’s harder for them to lose weight. Ozempic stimulate the hormones needed in the body for fat loss.”
It Can Help with Self-Esteem and Rarely Leads to Depression
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Dr. Decotiiis has seen a lot of positive effects on personality in her practice. “When people lose weight, they have better self-esteem, and they feel more confident in their own skin,” she says. “I have people who were using sedatives for anxiety or depression, and then when they took these drugs, they felt better and didn’t need them as much. My patient who had ADHD felt they had better focus and concentration. I have never had anyone who’s gone into depression or has felt worse after taking these drugs. My advice is to know who the patient is and supervise them accordingly.”
Ozempic Is Actually Only Approved for Those with Type 2 Diabetes
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According to the National Library of Medicine Ozempic is approved to control blood sugar levels in adults with type 2 diabetes when other medications do not control the sugar levels well enough.
It Can Also Help with Heart Health
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It is also used to reduce the risk of a stroke, heart attack, or death in adults who have type 2 diabetes along with heart and blood vessel disease. “It is not used to treat type 1 diabetes or diabetic ketoacidosis,” they say.
Wegovy Is Approved for Weight Loss
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“Semaglutide injection (Wegovy) is used to reduce the risk of a stroke, heart attack, or death in adults who are overweight or obese along with heart and blood vessel disease,” they say, adding that  “used along with an individualized low-calorie, low-fat diet and exercise program” it can help with weight loss “in obese adults or overweight adults who may also have high blood pressure, diabetes, or high cholesterol” and in obese children 12 years of age or older.
It Comes in a Prefilled Pen
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Semaglutide injection comes in a prefilled dosing pen injected once a week under the skin. “Use semaglutide injection on the same day each week at any time of day. You may change the day of the week that you use semaglutide as long as it has been 2 or more days (48 or more hours) since you used your last dose,” they say.
RELATED:What Happens to Your Body When You Stop Taking Ozempic
You Usually Start on a Low Dosage and Work Your Way Up
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Your doctor usually gets you started on a lower dosage, increasing it after four weeks. “Your doctor may increase your dose again after another four weeks based on your body's response to the medication,” they say.
Most Common Side Effects
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These are the most common side effects of Ozempic and Wegovy:
nausea
vomiting
diarrhea
abdominal pain
constipation
heartburn
burping
More Serious Side Effect
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There are also some potential serious side effects:
ongoing pain that begins in the upper left or middle of the stomach but may spread to the back, with or without vomiting
rash; itching; swelling of the eyes, face, mouth, tongue, or throat; or difficulty breathing or swallowing
decreased urination; or swelling of legs, ankles, or feet
vision changes
fainting or dizziness
pain in upper stomach; yellowing of skin or eyes; fever; or clay-colored stools (in those receiving semaglutide [Wegovy] for management of weight loss)
rapid heartbeat
dizziness, light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety or irritability or mood changes, hunger, weakness, or feeling jittery
RELATED:5 Foods That Maximize Weight Loss on GLP-1 Medicines, According to Coach
How Much Does Ozempic Cost?
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Just because your doctor prescribes Ozempic doesn’t mean insurance will cover it. The cost of Ozempic weighs heavily on whether your health insurance company believes that you qualify for the drug.
It’s Very Expensive Without Insurance
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Ozempic is expensive if your insurance refuses to cover it. According to GoodRX, without insurance Ozempic can cost as little as $937.98 per month and as much as $1,014 per month.
How Much Does Ozempic Cost with Insurance
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How much does it cost with insurance? Novo also offers a savings card, which enables people with private or commercial insurance to pay as little as $25 for a 1-month, 2-month, or 3-month supply of Ozempic for up to 24 months. However, many people pay more than that, with most insurance companies covering around 85 percent of the cost.
How Much Profit Are the Drug Companies Making?
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According to a study published in JAMA Network Open Trusted Source, these drugs “can likely be manufactured for prices far below current prices, enabling wider access.” Researchers from Yale University, King’s College Hospital in London, and the nonprofit Doctors Without Borders concluded that if the producers were charging $0.89 to $4.73 a month and still making a profit. This is in contrast to the nearly $1,000 per month list price charged by Novo Nordisk for Ozempic in the US.
RELATED:15 Things to Know Before Getting Ozempic for Weight Loss
What Is Rebound Weight Gain?
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After you stop taking Ozempic, there is a good chance you may gain the weight back. One study found that one year after stopping the drug, participants regained two-thirds of their prior weight loss.
Ozempic Face
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"Ozempic face" is one of the most popularized side effects of GLP-1 drugs. It’s actually a side effect of rapidly losing weight and isn’t a direct result of the drug. Losing weight fast can cause facial aging, including a hallowed look, wrinkles, and sunken eyes, explains Harvard Health.
RELATED: 15 Travel Habits That Help You Stay Fit and Lose Weight on the Go
Loose Skin and Excess Fat
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“Ozempic body” and “Ozempic butt” are two more trending terms to describe the sagging skin left behind as a result of rapid weight loss. After dropping weight fast, loose skin, pockets of stubborn fat, and stretch marks can be left behind. Treatments, including surgery, like liposuction and tummy tucks, and less invasive options, like CoolSculpting and EmSculpt Neo, as well as lasers, can help treat these conditions.
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        8 Best Ways to Maximize Ozempic Results
    

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By Christopher RobackJan 27, 2025
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Struggling to get the most out of your Ozempic prescription? Dr. Robert Cywes, known as the #CarbAddictionDoc to his 300,000 YouTube subscribers, specializes in treating obesity through a comprehensive approach that goes beyond just medication. As a leading expert in weight management, he underlines that success requires the right strategy. Here are his essential tips to maximize your results.

            
                Understand Your Medication's Role
            
            
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"Ozempic is a powerful tool, but it's not a magic solution," Dr. Cywes says in his post. "Think of it as a helper that makes it easier to implement the right habits." He explains that understanding how the medication works helps set realistic expectations and improves long-term success rates.
RELATED:20 Things You Need to Know About Ozempic and Weight Loss

            
                Focus on High-Quality Protein at Every Meal
            
            
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"Protein intake is crucial for preserving muscle mass during weight loss," explains Dr. Cywes. He recommends consuming at least 30 grams of protein at each main meal. "Without adequate protein, you risk losing muscle instead of fat. This is especially important when your appetite is reduced by Ozempic."

            
                Track Everything You Eat and Drink
            
            
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Dr. Cywes emphasizes, "Keeping a detailed food diary is non-negotiable. Even with reduced appetite from Ozempic, you need to understand your eating patterns to succeed." He suggests using a digital tracking app and recording meals immediately to ensure accuracy. "The most successful patients are those who track consistently, not just on their 'good' days."

            
                Stay Ahead of Side Effects
            
            
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"Proper hydration and proactive side effect management can make or break your success," Dr. Cywes states. He advises drinking a minimum of 64 ounces of water daily. "Most side effects can be managed effectively if caught early. Don't wait until they become severe to address them."
RELATED:20 Possible Ozempic Side Effects

            
                Develop a Consistent Movement Routine
            
            
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"Physical activity becomes easier as the weight comes off," notes Dr. Cywes. "Start with daily walking and gradually increase your activity level. The goal isn't to exhaust yourself but to build sustainable habits." He recommends beginning with 10-minute walks and slowly increasing duration and intensity.

            
                Address Emotional Eating Patterns
            
            
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"While Ozempic helps control physical hunger, emotional eating requires different tools," Dr. Cywes explains. "Many patients discover that their eating habits are more tied to emotions than hunger." He recommends working with mental health professionals to develop healthy coping strategies and identifying specific emotional triggers.

            
                Build Your Support Network
            
            
        ShutterstockDr. Cywes observes that "patients with strong support systems consistently achieve better outcomes." He suggests joining both online and in-person support groups: "Having people who understand your journey makes a significant difference. Your support network can provide accountability, encouragement, and practical tips."
RELATED:What Happens to Your Body When You Stop Taking Ozempic

            
                Monitor Multiple Progress Markers
            
            
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"Success isn't just about the number on the scale," says Dr. Cywes. "Focus on non-scale victories too." He recommends tracking multiple indicators: "Take monthly progress photos, measure body circumferences, monitor energy levels, and note improvements in daily activities. These measurements often show progress even when the scale doesn't move."

            
                Create a Sustainable Meal Structure
            
            
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"Ozempic reduces hunger, but you still need a structured approach to eating," Dr. Cywes advises. "Plan your meals in advance and establish regular eating times. This structure helps prevent both undereating and impulsive food choices."

            
                Prepare Strategies for Plateaus
            
            
        Shutterstock"Weight loss plateaus are normal and temporary," Dr. Cywes reassures. "The key is to have specific strategies ready before they happen." He suggests keeping a list of proven plateau-breaking techniques: "Adjust portion sizes, increase protein intake, vary your exercise routine, or review your food diary for hidden calories. The goal is to make small, sustainable changes rather than drastic ones."
RELATED:20 Things to Avoid While on Ozempic

            
                Plan for Long-Term Success
            
            
        Shutterstock"The most successful patients think beyond just the weight loss phase," Dr. Cywes emphasizes. "They develop habits and strategies that will serve them well after reaching their goal weight." He recommends creating a maintenance plan early in your journey: "Consider how you'll adjust your habits as your needs change, and always keep communication open with your healthcare team." And if you enjoyed this article, don't miss20 Incredible Ozempic Success Stories of All Time.
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        5 Key Benefits of Ozempic for Weight Management Explained
    

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By Catherine Gervacio, rnd, certified exercise nutrition coachJul 04, 2024
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The five key benefits of Ozempic for weight management are top of mind for me, as a Registered Nutritionist-Dietitian and Certified Exercise Nutrition Coach with 5 years of experience in a clinical setup and over 10 years in the health and fitness industry. With backgrounds in clinical nutrition and exercise coaching, I have a deep understanding of energy and nutrient metabolism and how it affects health and lifestyle choices. 
In my experience, weight management involves maintaining a healthy balance between the calories consumed and the calories expended through physical activity. Everyone has different weight goals based on factors such as age, gender, body composition, and health conditions. Therefore, a customized plan allows for the establishment of realistic and achievable goals tailored to the individual's specific circumstances. And in some cases, this can include Ozempic.
Ozempic is a prescription medication that mimics the effects of GLP-1, which helps regulate blood sugar levels. This influences feelings of fullness and reduces appetite. It is primarily used to treat type 2 diabetes but has also shown benefits in weight management.
I think Ozempic stands out among weight management treatments due to its dual action in managing both blood sugar levels and promoting weight loss. Also, clinical trials have demonstrated substantial weight loss in individuals using Ozempic. This makes it one of the more effective medications in this regard. Here are the top five benefits.
Benefit #1: Enhanced Weight Loss
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I would say enhanced weight loss. As I mentioned above, Ozempic contains the active ingredient semaglutide works by mimicking the effects of GLP-1, it slows down digestion, increases feelings of fullness, and reduces appetite. This leads to a decrease in caloric intake and, consequently, promotes significant weight loss. The enhanced weight loss observed with Ozempic has been demonstrated in clinical trials, making it a notable feature of its effectiveness in managing body weight. (Research here, here and here.)
Benefit #2: Reduction of Appetite
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The second key benefit is the reduction of appetite which I explained above. To explain this in easy, understandable terms, Ozempic works by slowing down the process of breaking down food in the stomach. It's like telling the stomach, "Hey, take it easy, we've got enough energy for now." This slowing down of digestion helps in the feeling of fullness, thereby reducing appetite.
Related: Which Pasta is Best for Weight Loss?
Benefit #3: Blood Sugar Regulation
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In connection to the two, the next benefit would be blood sugar regulation. Since Ozempic can slow down the process of breaking food, it encourages the pancreas to release insulin only when needed. This then helps regulate the amount of sugar in the blood. Stable blood sugar levels contribute to reduced cravings and support overall weight management by minimizing the impact of fluctuating glucose levels on appetite and energy intake. 
Benefit #4: Cardiovascular Health Support
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The fourth benefit would be cardiovascular health support, considering that excess weight and diabetes are often associated with an increased risk of heart-related issues. In a study, it demonstrated a reduction in the risk of major cardiovascular events, such as heart attacks and strokes, in individuals with type 2 diabetes.
Benefit #5: Sustainable Lifestyle Changes
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If all is managed well, the fifth benefit I would say is sustainable lifestyle changes. Ozempic complements lifestyle modifications by making it easier for individuals to adopt and sustain healthier eating habits and engage in regular physical activity. The medication helps in curbing appetite and promoting a feeling of fullness, which can help in sticking to a reduced-calorie diet. This synergy between medication and lifestyle adjustments enhances the overall effectiveness of the weight management plan, promising lasting healthy habits.
Possible Side Effects of Ozempic
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Yes, like any medication, Ozempic also comes with potential side effects. These include nausea, vomiting, diarrhea, constipation, hypoglycemia, and even reactions to site injections. Again, as with any medication, the benefits and risks should be evaluated on an individual basis. A qualified healthcare professional can provide personalized advice based on a thorough assessment of the individual's health status and medical history, so it's best to ask for their recommendation before taking Ozempic. 
​​Related: Courtney Black Shares Before-and-After Slimdown Snaps After “Reverse Dieting”
Ozempic Should Not be the Sole Solution
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Ozempic can be a valuable tool to incorporate other healthy lifestyle habits. It shouldn't be the sole solution to achieve any health and fitness goals. It's still best to 
focus on a balanced diet, regular physical activity, and behavioral strategies to maximize the benefits of weight management. Also, individual responses to medications can vary. What works well for one person may not have the same effects for another. Pay attention to how your body responds and communicate any concerns with a healthcare provider. Concerning that, it's always best to regularly monitor your progress with the guidance of your healthcare provider. This includes tracking weight changes, blood sugar levels (if applicable), and any potential side effect.
💪🔥Body Booster: Ozempic helps you feel full, so you eat less. This makes it easier to stick to a healthy diet and exercise regularly. When you manage this well, it can lead to lasting healthy habits
Catherine Gervacio is a Registered Dietician and nutrition writer for Living.Fit.
Nutrition & Diet
        7 Natural Food Boosters That Work Like Ozempic
    

        Copyright drkateld/YouTube
    
By Christopher RobackFeb 03, 2025
Christopher Roback
Professional Health, Science Editor and Writer
Christopher Roback is an experienced news journalist specializing in political, science, and crime news.
 See Full Bio 
✓Evidence-Based
This content references scientific studies and academic research, and is fact-checked to ensure accuracy.
Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.
We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.
Struggling with weight loss? You're among the 165 million Americans trying to shed extra pounds. While medications like Ozempic make headlines, their high cost and side effects leave many searching for alternatives. Dr. Kate Lyzenga-Dean, a Functional Medicine Healthcare Provider with over a decade of experience, reveals seven natural ways to boost your body's own GLP-1 production for sustainable weight loss. Discover how these science-backed alternatives could help you achieve your weight loss goals without breaking the bank or dealing with uncomfortable side effects.

            
                What is GLP-1 and Why Does it Matter for Weight Loss?
            
            
        "GLP-1 is a hormone that's made in your gut when you eat," Dr. Kate explains in her post. This crucial hormone performs multiple functions: signaling your pancreas to release insulin, improving satiety, and slowing down food digestion. Unlike medications that artificially boost GLP-1 activity, natural alternatives work with your body's own mechanisms for sustainable results.

RELATED:20 Things You Need to Know About Ozempic and Weight Loss

            
                The Problem with GLP-1 Medications
            
            
        ShutterstockDr. Kate highlights significant drawbacks of GLP-1 medications: "These drugs are expensive and rarely covered by insurance for folks who don't meet strict criteria." She notes that "50% of patients taking GLP-1 agonists experienced nausea," and according to a 2022 study, most participants regained their weight within a year after stopping the medication.

            
                Natural Booster #1: Healthy Fats
            
            
        Shutterstock"Often you need to eat more fat to lose fat," Dr. Kate reveals. Research shows that unsaturated, long-chain fatty acids strongly stimulate GLP-1 release. She specifically points to a study where "85 grams of pistachios" increased GLP-1 concentrations in overweight adults. Additionally, following a Mediterranean diet rich in olive oil for 28 days significantly boosted post-meal GLP-1 levels.

            
                Natural Booster #2: Protein-Rich Foods
            
            
        ShutterstockResearch has found that "meals with higher amounts of protein stimulate GLP-1 secretion better than those with mostly carbs," Dr. Kate explains. She recommends eggs, which contain beneficial unsaturated fats and choline, and plain yogurt, which studies show can significantly increase GLP-1 production.

RELATED:20 Possible Ozempic Side Effects

            
                Natural Booster #3: Flavonoid-Rich Spices
            
            
        ShutterstockDr. Kate identifies key spices that boost GLP-1: "Curcumin, the primary chemical in turmeric... cinnamon and rosemary." She also mentions green tea's EGCG content, though notes that concentrated supplements may be needed for optimal results.

            
                Natural Booster #4: Berberine
            
            
        Shutterstock"One of the natural GLP-1-boosting herbs that's getting a lot of attention is berberine," Dr. Kate shares. A meta-analysis found that "just one gram of concentrated berberine significantly lowered cholesterol, BMI, weight, fasting glucose, hemoglobin A1c, and other metabolic markers."

            
                Natural Booster #5: Gut-Supporting Probiotics
            
            
        ShutterstockDr. Kate emphasizes the importance of healthy gut bacteria: "These healthy bugs make compounds called postbiotics, one category being short-chain fatty acids." She specifically mentions the bacteria Akkermansia, which not only increases GLP-1 but also enhances fat burning through thermogenesis.

RELATED:What Happens to Your Body When You Stop Taking Ozempic

            
                Natural Booster #6: Polyphenol-Rich Foods
            
            
        ShutterstockTo support beneficial gut bacteria, Dr. Kate recommends polyphenols, noting that "the ones found in pomegranate are especially good at supporting Akkermansia." This creates a synergistic effect, enhancing both gut health and GLP-1 production.

            
                Natural Booster #7: Mediterranean Diet
            
            
        ShutterstockDr. Kate points to research showing that following a Mediterranean diet, particularly one rich in olive oil, significantly increases GLP-1 levels. This dietary pattern combines many of the individual boosters into a sustainable eating approach.

RELATED:20 Things to Avoid While on Ozempic

            
                Combining Natural GLP-1 Boosters for Maximum Results
            
            
        Shutterstock"The beauty of working with your body using natural GLP-1 boosters is that you can stack these strategies to maximize your weight loss and blood sugar balance," Dr. Kate explains. While these natural alternatives won't deliver overnight results like medications, they offer a sustainable path to weight management with minimal side effects. And if you enjoyed this article, take advantage of these20 Superfoods for People Over 50.
Nutrition & Diet
        10 Insider Tips to Know Before Taking Ozempic
    

        Mom of 4 Lost 55 Pounds on Semaglutide "Now I Finally See Myself in the Mirror"
    

        Copyright karli.sine/Instagram/Shutterstock
    
By Leah GrothFeb 27, 2025
Leah Groth
Writer, Editor, and Content Creator
Leah Groth has decades of experience covering all things health, wellness and fitness related. 
 See Full Bio 
                       Follow:
                       
✓Evidence-Based
This content references scientific studies and academic research, and is fact-checked to ensure accuracy.
Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.
We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.
Are you considering going on a weight loss drug to drop pounds? You should know a few things before doing so, says one experienced weight loss warrior. Karli Sine is a social media influencer who lost 55+ lbs on Semaglutide and is now “microdosing Tirzepatide,” she writes in her Instagram bio. In a new post, she opens up about her journey, revealing some insider tips on how to maximize weight loss and minimize side effects. “You’re starting your GLP-1 journey and ready to see big changes?” she writes. “Here are some things that aren’t in every post or pamphlet—but you’ll wish you knew them! I speak from experience!!! I lost 55 lbs taking Semaglutide! Your journey will be unique, and I want to make sure you’re set up for success.”

            
                The First Months are Introductory Doses
            
            
        
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A post shared by Karli Sine | GLP-1 Support & Motivation (@karli.sine)
The first thing to know is that the first months are introductory doses. “GLP-1s like Semaglutide and Tirzepatide aren’t a race. Starting with a lower dose helps your body adjust, reduces side effects, and builds a solid foundation for results. Don’t expect weight loss after a week or even a month, you JUST started!” she writes.
RELATED: 15 Things to Know Before Requesting Ozempic for Weight Loss

            
                Stay Hydrated But With Electrolytes
            
            
        
View this post on Instagram
A post shared by Karli Sine | GLP-1 Support & Motivation (@karli.sine)
Next, hydration is key. “Increased water is crucial, but plain water isn’t enough. GLP-1s slow gastric emptying, so add electrolytes to prevent fatigue and headaches,” she says. 

            
                Protein is Non-Negotiable
            
            
        
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A post shared by Karli Sine | GLP-1 Support & Motivation (@karli.sine)
You also need to make sure you are consuming enough protein. “With reduced appetite, protein intake often drops, risking muscle loss. Aim for 90–120g daily, and prioritize it at every meal to preserve lean muscle while losing fat,” she writes.
RELATED:20 Possible Ozempic Side Effects

            
                Resistance Training MATTERS
            
            
        
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A post shared by Karli Sine | GLP-1 Support & Motivation (@karli.sine)
You need to resistance train if you want to maximize weight loss. “GLP-1s give you a leg up, but strength training will improve results, reduce loose skin, boost energy levels and help protect your muscles,” she writes.

            
                Side Effects? Prep Ahead
            
            
        
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A post shared by Karli Sine | GLP-1 Support & Motivation (@karli.sine)
Side effects are inevitable, but prepping ahead can minimize them.
Nausea: “Keep ginger chews or peppermint oil handy. Get Zofran if possible for the bad days,” she suggests. 
Constipation: “Magnesium glycinate and high-fiber foods like Inulux Fiber can help,” she says. 
Fatigue: “B12 or NAD+ injections can be game changers,” she notes.

            
                It’s Not Just About Weight Loss
            
            
        
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A post shared by Karli Sine | GLP-1 Support & Motivation (@karli.sine)
Going on a weight loss drug will do more than help you lose weight. “GLP-1s improve insulin resistance, lower inflammation, reduce cravings, and even improve cardiovascular health. Celebrate all the wins, not just the scale,” she writes. 
RELATED:What Happens to Your Body When You Stop Taking Ozempic

            
                Expect Plateaus
            
            
        
View this post on Instagram
A post shared by Karli Sine | GLP-1 Support & Motivation (@karli.sine)
Your weight may plateau. “They’re normal and don’t mean failure. Use plateaus as a time to reassess nutrition, hydration, and activity. Try a new injection site or upping your water!” she says. 

            
                Consistency Is King
            
            
        
View this post on Instagram
A post shared by Karli Sine | GLP-1 Support & Motivation (@karli.sine)
Stay consistent. “Weekly doses are ideal, so stick to the same day and time to stay on track. Set alarms or reminders if needed,” she suggests.
RELATED:20 Things to Avoid While on Ozempic

            
                Prepare for Questions or Judgement
            
            
        
View this post on Instagram
A post shared by Karli Sine | GLP-1 Support & Motivation (@karli.sine)
People might ask you a lot of questions about weight loss drugs, or even judge you. “Educate yourself on how it works—it’s not a shortcut; it’s science. Confidence in your choice shuts down negativity,” she says.

            
                Stay the Course Post-Goal
            
            
        
View this post on Instagram
A post shared by Karli Sine | GLP-1 Support & Motivation (@karli.sine)
And lastly, stay the course even after you hit your weight loss goal. “GLP-1s aren’t a ‘one and done’ solution. Many people stay on low doses long-term to maintain insulin resistance, reduce cravings, or prevent weight regain,” she says. And if you enjoyed this article, don't miss20 Incredible Ozempic Success Stories of All Time.
Nutrition & Diet
        She Lost 80 Pounds on Ozempic: 5 Side Effects
    

        Copyright sherry.anna.shares/Instagram
    
By Leah GrothFeb 27, 2025
Leah Groth
Writer, Editor, and Content Creator
Leah Groth has decades of experience covering all things health, wellness and fitness related. 
 See Full Bio 
                       Follow:
                       
✓Evidence-Based
This content references scientific studies and academic research, and is fact-checked to ensure accuracy.
Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.
We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.
Are you considering going on Ozempic or another GLP-1 weight-loss drug? Understanding the side effects is essential before going on any type of medication. Sherry Steele is an influencer who has been on a GLP-1 medication for about a year and has lost 80 pounds, according to one of her most recent posts. In a recent Instagram video, she reveals the side effects she has come across while on the drug. “What side effects have I experienced on a GLP-1 in the last 11 months in no particular order?” she writes. 

            
                People Regularly Ask Her About Ozempic Side Effects
            
            
        
View this post on Instagram
A post shared by Sherry Steele (@sherry.anna.shares)
She starts by saying that lots of people are curious about what to expect while on a weight loss drug. “Side effects is one of the most common questions I get so I thought I’d put it all in one place,” she says.
RELATED: 15 Things to Know Before Requesting Ozempic for Weight Loss

            
                Headaches
View this post on Instagram
A post shared by Sherry Steele (@sherry.anna.shares)
The first side effect? “I experienced a headache in the beginning. I dealt with a headache for months and managed it with fluids, sleep, over-the-counter meds, and supplements,” she says. 

            
                Nausea
            
            
        
View this post on Instagram
A post shared by Sherry Steele (@sherry.anna.shares)
The second side effect she experienced is a common one, nausea. “I only experience nausea ever so slightly the very first day. This is a common side effect and I really just didn't experience it,” she says. 

            
                Constipation
            
            
        
View this post on Instagram
A post shared by Sherry Steele (@sherry.anna.shares)
She also had trouble with constipation. “This gets managed as my body gets used to increased doses, adequate amounts of water and fiber, and supplements,” she says.
RELATED:20 Possible Ozempic Side Effects

            
                Food Noise Quieting
            
            
        
View this post on Instagram
A post shared by Sherry Steele (@sherry.anna.shares)
“My favorite side effect, food noises,” she says, noting that the medication helps keep “food noise is at bay,” which is key for weight loss. “I've always known how to lose weight. This side effect helps me to actually accomplish the weight loss through diet,” she says.
RELATED:What Happens to Your Body When You Stop Taking Ozempic

            
                Slightly Blurred Vision
            
            
        
View this post on Instagram
A post shared by Sherry Steele (@sherry.anna.shares)
“One side effect (unusual) that I did not mention in the reel is how I’ve experienced sugar drops,” she added in the caption of the post. “I can tell because there have been a handful of times where my vision has slightly blurred, and I felt better upon getting some sugar into my system, which I have spoken to my doctor about and I now go for protein. I have also tested my fasting glucose a couple of times and it’s been in the 40s. This is not a chronic issue and can be managed by diet (another reason I’m working with a RD). I think it’s also important to note that I experienced some sugar drop issues prior to ever being on the meds. I’m just thinking the meds could be enhancing that.” And if you enjoyed this article, don't miss20 Incredible Ozempic Success Stories of All Time.
Fitness & Workouts
        Coach Transformed Body at 40 by Ditching CrossFit
    

        Copyright nutrition.by.kathe/Instagram
    
By Leah GrothFeb 26, 2025
Leah Groth
Writer, Editor, and Content Creator
Leah Groth has decades of experience covering all things health, wellness and fitness related. 
 See Full Bio 
                       Follow:
                       
✓Evidence-Based
This content references scientific studies and academic research, and is fact-checked to ensure accuracy.
Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.
We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.
Are you training hard and taking extreme measures with your diet but can’t seem to lose weight? You might need to tone things down, one expert says. Kathe Martin is a certified nutrition coach who helps women transform their bodies via nutrition and exercise. In a new post, she shares her dramatic before-and-after photo, revealing how she smartened up her approach to losing weight. “Transformation Over 40—But It Didn’t Happen Overnight,” she writes in the caption, revealing the simple tactics she used to lose weight. “The key? Dialing in my nutrition and training smarter, not harder,” she writes. Here is what she did: 

            
                There Is No Quick Fix
            
            
        
View this post on Instagram
A post shared by Kathe Martin (@nutrition.by.kathe)
“This isn’t a 6-week challenge or a quick-fix diet. This is years of consistency, trial and error, setbacks, and breakthroughs. Progress wasn’t linear—I had my ups and downs, moments of doubt, and times when I felt like I was doing everything right but still wasn’t seeing the results I wanted,” she writes.

            
                She Dialed in Her Nutrition
            
            
        
View this post on Instagram
A post shared by Kathe Martin (@nutrition.by.kathe)
“The real shift happened when I finally dialed in my nutrition. No more extreme dieting, no more chasing quick fixes—just fueling my body in a way that actually worked for me,” she continued. 

            
                She Changed Her Approach to Fitness, Running Less
            
            
        
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A post shared by Kathe Martin (@nutrition.by.kathe)
She also had to change her approach to fitness. “And as much as I love running, I had to face a hard truth: more wasn’t always better. I used to run five days a week, thinking that was the key to getting lean, but in reality, I needed more balance,” she writes.

            
                Now She Runs Twice a Week
            
            
        
View this post on Instagram
A post shared by Kathe Martin (@nutrition.by.kathe)
She now balanced cardio with strength. “Now, I still run (because I love it and always will! 🏃♀️), but just twice a week (only during race season), while making lifting the priority.”

            
                She Lifts Weights and Does Low-Intensity Workout
            
            
        
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A post shared by Kathe Martin (@nutrition.by.kathe)
She also started lifting weights. “Strength training and low intensity gave me the results I had been chasing for years,” she reveals.

            
                She Used to Do CrossFit
            
            
        
View this post on Instagram
A post shared by Kathe Martin (@nutrition.by.kathe)
“I was never this strong or this lean in all my years of CrossFit. I worked hard, but I was constantly under-fueling, overdoing cardio, and stuck in the mindset that more was better. Turns out, smarter was better,” she admits.

            
                It Takes Time and Commitment
            
            
        
View this post on Instagram
A post shared by Kathe Martin (@nutrition.by.kathe)
“So if you’re feeling stuck, frustrated, or like your progress isn’t happening fast enough—just know, this takes TIME. But if you stay consistent, work smarter (not harder), and trust the process… the results WILL come.” And if you enjoyed this article, take advantage of these 15 Quick Ways to Lose Body Fat Percentage in a Week.
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