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15 Reasons Ozempic May Not Be Working for You

Here’s what might be causing the issue.
FACT CHECKED BY Christopher Roback

Ozempic is highly effective for weight loss—but what if it's not working for you? "While Ozempic can enhance weight-loss results, it's not a magic bullet. The way the body responds to Ozempic varies among individuals," says the Mayo Clinic. "Factors such as genetics, metabolic rate, and overall health can influence the impact of the medication on weight-loss progress." Here are 15 reasons you might not be losing weight on Ozempic.

Dosage Issues


The correct dosage of Ozempic varies from person to person. "In clinical trials, Ozempic has shown promising results at standard doses," says the Mayo Clinic. "However, in some cases, healthcare providers may adjust the dosage based on individual needs. Discussing the dosage with your healthcare provider is crucial to ensuring that you are on the right track for weight-loss success."

You're Not Exercising

Overweight guy sitting on the couch with remote in hand trying to watch some TV.

Ozempic is not an excuse to give up on your fitness regimen. "There are added benefits for people with diabetes," says Harvard Health. "Exercise lowers blood glucose levels and boosts your body's sensitivity to insulin, countering insulin resistance."

It's Too Early

Santiago, Chile, august 16th, 2023. Pen injection of semaglutide named

Ozempic may take a while to kick in, depending on dosage. Some people start on a low dose and work their way up. Be patient!

RELATED: 20 Incredible Ozempic Success Stories of All Time

Unhealthy Lifestyle

Fast food concept. Unhealthy food. Unhealthy food and fast food with donuts, chocolate, burgers and sweets top view

Ozempic works side-by-side with healthy lifestyle changes. "Are you eating a balanced diet that includes a variety of fruits, vegetables, whole grains, and lean proteins? Or are you relying heavily on processed foods, sugary snacks, and fast food?" says the Mayo Clinic. "Evaluating your diet can help you identify areas for improvement and make necessary changes to support your overall well-being."

Not Taking It Every Day

GDANSK, POLAND - MAY 2022: obese fat man preparing Semaglutide Ozempic injection control blood sugar levels

Ozempic is designed to be taken every day, so follow the instructions your doctor provided. "If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule," says the Mayo Clinic. "Do not double doses."

Food Noise

Romantic sunset dinner on beach. Table honeymoon set for two with luxurious food, glasses of champagne drinks in restaurant with sea view and yachts on background. Summer vacation or wedding concept.

Many people who take Ozempic say that the "food noise" is turned off. If that's not the case, Ozempic may not be right for you. "Some finally feel relieved of that pressure of thinking about a food or pressure of trying not to think about the food when the food is in their mind," Anastassia Amaro, MD, tells Penn Medicine. "And others, actually, may not like it as much because they may be losing their social life over it. They are not interested in going out. They're not interested in hosting parties."

Medical Conditions

Female doctor measuring waist of overweight woman with measuring tape in clinic

Underlying medical conditions could prevent Ozempic from working properly. Always get a full check-up with a medical professional to rule out any health problems. Talk to your doctor if there's any concern at all.

RELATED: 20 Things You Need to Know About Ozempic and Weight Loss

Try a Different Drug

Never fear, your pharmacist is here. Cropped shot of an attractive young female pharmacist working in a pharmacy.

Ozempic is not meant for weight loss but for treating type 2 diabetes. It might be worth looking into a different drug specifically designed for weight loss, such as Wegovy. Ask your doctor about alternatives if Ozempic is not working.

Incorrect Injecting

GDANSK, POLAND - MAY 2022: obese fat man preparing Semaglutide Ozempic injection control blood sugar levels

It's very important to inject Ozempic correctly. "To ensure proper injection technique, injecting the medication below the skin in the abdomen, thigh, or upper arm is essential," according to When doing this, paying careful attention to the injection site is important to avoid any complications."

Rotate Injection Site

Ozempic Insulin injection pen or insulin cartridge pen for diabetics. Medical equipment for diabetes parients. Copenhagen, Denmark - May 17, 2023.

Don't use the same injection site for each shot. "Rotating injection sites can increase the effectiveness of semaglutide in controlling blood sugar levels," according to "Injecting the medication in different areas of your body reduces pressure on each location. It improves the chances of a steady amount of the medicine being absorbed into your system with each dose."

Drinking Alcohol

Multiracial group of happy friends having fun while toasting with beer in a bar.

Drinking alcohol while taking Ozempic can be dangerous for people with type 2 diabetes. While many people lose the desire to drink alcohol, those who do are risking low blood sugar (hypoglycemia). Alcohol can also make gastrointestinal side effects worse.

RELATED: 20 Possible Ozempic Side Effects

Too Much Stress

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Stress can negatively impact your metabolism. "Things like exercise, meditation, mindfulness exercises, relaxation — those are ways that we can work toward good stress management, as well as good weight management," Leslie Heinberg, PhD, tells the Cleveland Clinic.

Unrealistic Expectations

Menopausal Mature Woman Concerned With Weight Gain Standing On Scales In Bedroom At Home

Don't compare your progress on Ozempic to other people—everybody reacts to drugs differently. Factors such as starting weight and lifestyle can make a difference. If you feel you're doing everything correctly and Ozempic is still not effective, talk to your doctor.


Montreal, CA - 25 November 2023: Hand holding Ozempic semaglutide injection pen. Ozempic is a medication for obesity

Some people simply don't respond to the drug for a variety of possible reasons. "Typically, the people that are non-responders tend to be sicker," says Gitanjali Srivastava, internist and director of the obesity medicine program at Vanderbilt University Medical Center. "They tend to have more complicated metabolic derangements. They have a lot of complications [like] psychosocial issues that may be going on in their life."

RELATED: 20 Things to Avoid While on Ozempic

Goal Weight Reached

Full length of excited Indian woman sitting on scales at home, overjoyed with success of her slimming diet, side view. Emotional Asian lady achieving her weight loss goal, making YES gesture

The more weight you have to lose, the more you will lose at the start. Depending on your starting weight, expect weight loss to slow down or plateau altogether as you reach your goal weight. Talk to your doctor about what a healthy weight is for you.

💪🔥Body Booster: When in doubt, talk to your doctor about progress on Ozempic.

Ferozan Mast
Ferozan Mast is a science, health and wellness writer with a passion for making science and research-backed information accessible to a general audience. Read more