15 Reasons Ozempic May Not Be Working for You

Ozempic is highly effective for weight loss—but what if it’s not working for you? “While Ozempic can enhance weight-loss results, it’s not a magic bullet. The way the body responds to Ozempic varies among individuals,” says the Mayo Clinic. “Factors such as genetics, metabolic rate, and overall health can influence the impact of the medication on weight-loss progress.” Here are 15 reasons you might not be losing weight on Ozempic.

Dosage Issues

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The correct dosage of Ozempic varies from person to person. “In clinical trials, Ozempic has shown promising results at standard doses,” says the Mayo Clinic. “However, in some cases, healthcare providers may adjust the dosage based on individual needs. Discussing the dosage with your healthcare provider is crucial to ensuring that you are on the right track for weight-loss success.”

You’re Not Exercising

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Ozempic is not an excuse to give up on your fitness regimen. “There are added benefits for people with diabetes,” says Harvard Health. “Exercise lowers blood glucose levels and boosts your body's sensitivity to insulin, countering insulin resistance.”

It’s Too Early

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Ozempic may take a while to kick in, depending on dosage. Some people start on a low dose and work their way up. Be patient!

RELATED: 20 Incredible Ozempic Success Stories of All Time

Unhealthy Lifestyle

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Ozempic works side-by-side with healthy lifestyle changes. “Are you eating a balanced diet that includes a variety of fruits, vegetables, whole grains, and lean proteins? Or are you relying heavily on processed foods, sugary snacks, and fast food?” says the Mayo Clinic. “Evaluating your diet can help you identify areas for improvement and make necessary changes to support your overall well-being.”

Not Taking It Every Day

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Ozempic is designed to be taken every day, so follow the instructions your doctor provided. “If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule,” says the Mayo Clinic. “Do not double doses.”

Food Noise

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Many people who take Ozempic say that the “food noise” is turned off. If that’s not the case, Ozempic may not be right for you. “Some finally feel relieved of that pressure of thinking about a food or pressure of trying not to think about the food when the food is in their mind,” Anastassia Amaro, MD, tells Penn Medicine. “And others, actually, may not like it as much because they may be losing their social life over it. They are not interested in going out. They're not interested in hosting parties.”

Medical Conditions

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Underlying medical conditions could prevent Ozempic from working properly. Always get a full check-up with a medical professional to rule out any health problems. Talk to your doctor if there’s any concern at all.

RELATED: 20 Things You Need to Know About Ozempic and Weight Loss

Try a Different Drug

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Ozempic is not meant for weight loss but for treating type 2 diabetes. It might be worth looking into a different drug specifically designed for weight loss, such as Wegovy. Ask your doctor about alternatives if Ozempic is not working.

Incorrect Injecting

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It’s very important to inject Ozempic correctly. “To ensure proper injection technique, injecting the medication below the skin in the abdomen, thigh, or upper arm is essential,” according to BrandonRichlandMD.com. When doing this, paying careful attention to the injection site is important to avoid any complications.”

Rotate Injection Site

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Don’t use the same injection site for each shot. “Rotating injection sites can increase the effectiveness of semaglutide in controlling blood sugar levels,” according to BrandonRichlandMD.com. “Injecting the medication in different areas of your body reduces pressure on each location. It improves the chances of a steady amount of the medicine being absorbed into your system with each dose.”

Drinking Alcohol

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Drinking alcohol while taking Ozempic can be dangerous for people with type 2 diabetes. While many people lose the desire to drink alcohol, those who do are risking low blood sugar (hypoglycemia). Alcohol can also make gastrointestinal side effects worse.

RELATED:20 Possible Ozempic Side Effects

Too Much Stress

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Stress can negatively impact your metabolism. “Things like exercise, meditation, mindfulness exercises, relaxation — those are ways that we can work toward good stress management, as well as good weight management,” Leslie Heinberg, PhD, tells the Cleveland Clinic.

Unrealistic Expectations

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Don’t compare your progress on Ozempic to other people—everybody reacts to drugs differently. Factors such as starting weight and lifestyle can make a difference. If you feel you’re doing everything correctly and Ozempic is still not effective, talk to your doctor.

Non-Responders

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Some people simply don’t respond to the drug for a variety of possible reasons. "Typically, the people that are non-responders tend to be sicker," says Gitanjali Srivastava, internist and director of the obesity medicine program at Vanderbilt University Medical Center. "They tend to have more complicated metabolic derangements. They have a lot of complications [like] psychosocial issues that may be going on in their life."

RELATED:20 Things to Avoid While on Ozempic

Goal Weight Reached

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The more weight you have to lose, the more you will lose at the start. Depending on your starting weight, expect weight loss to slow down or plateau altogether as you reach your goal weight. Talk to your doctor about what a healthy weight is for you.

💪🔥Body Booster: When in doubt, talk to your doctor about progress on Ozempic.

Are you on Ozempic or another semaglutide but don’t feel like you are losing weight? There are a number of reasons the scale might not be budging, according to one expert. Dr. Jessie Watkins of Watkins Metabolic Clinic is a Canada-based weight loss specialist. In a recent viral video, she answers a question that she frequently asks her patients: Why aren't I losing weight on Ozempic?

1. Ozempic Vs. Wegovy

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Dr. Watkins explains that Ozempic is a brand name for semaglutide, which is marketed at one milligrams a week for diabetes, while Wegovy is marketed at 2.4 milligrams a week for weight loss. “But regardless of what medication you're on for weight loss, it's important to remember that different medications work differently to help you lose weight. So, one medication may or may not be a great fit for you, and another may be very beneficial. So it's important to have a comprehensive discussion with your physician before choosing the best medication for you,” she says.

2. You Started Off on a Low Dose

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“Regardless of whichever medication you're on, all of them start at a really low dose and go up slowly, and it's very common to not lose weight or even see the scale budge at those early low introductory doses,” she says. She explains that the purpose of low doses “is to help your body get used to the medication and reduce side effects as opposed to seeing weight loss right off the bat.”

3. You Are Only Losing One to Two Pounds Per Week

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The first reason why you might not think the drug is working is if you expect to lose weight miraculously fast. “The other frustrating thing that can happen is social media is full of claims of rapid, significant weight loss with Ozempic when really it's more realistic to see about one or two pounds a week of weight loss,” she says.

4. IYou Are Experiencing Bloating and Constipation

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Another reason why you might be thinking you aren’t losing weight? “When you're first starting a medication, it's very common to feel bloated and constipated, so you may actually be losing weight and burning fat, but the number on the scale may not budge,” she says. “And it can also be frustrating that in the past, when you've gone on a really restrictive diet, you might have lost weight faster.”

5. You Have to Prioritize Long-Term Sustainability

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“The key and the goal with this medication is long-term sustainable weight loss maintenance as opposed to a dramatic weight loss over a few months,” she says. “That's really hard to maintain on a super restrictive fad diet. It's also important to make sure that you're not burning muscle instead of fat tissue. So you wanna make sure to keep your protein intake high and to incorporate resistance training into your exercise routine.”

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6. You Plateau

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Another reason you might not think the drug is working? You plateau. “Also, remember that your weight loss will plateau eventually. You're not gonna lose weight forever on semaglutide because it would be unsafe to do so. And again, the frustrating piece here is that we can't predict where each person will plateau eventually. So it's really individualized based on the patient,” she says.

7. You Haven’t Reduced Your Caloric Intake

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“Now, the most important take-home reason why you might not be losing weight on semaglutide is if you haven't reduced your calorie intake. In order for this medication to help you lose weight, you have to be in a calorie deficit. And so if you're eating exactly the same number of calories you ate before starting the medication and you're hoping to lose weight, you're simply not going to see that change.”

RELATED: 19 Bad Habits I Gave Up to Lose 100 Pounds

8. You Are Too Stressed

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Other factors that can also impact or sabotage your weight loss attempt? “Chronic stress,” says Dr. Watkins.

9. You Are On Other Medications That Cause Weight Gain

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Another reason why you might not be losing weight while on Ozempic? You might be taking other medications that actually cause weight gain, says Watkin.

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10. Poor Sleep

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Sleep also impacts weight loss, says Dr. Watkins. According to the Sleep Foundation, getting enough z’s is a mood booster, promotes heart health, regulates blood sugar, improves mental function, restores your immune system, helps relieve stress, and aids in weight loss. And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.

Ozempic is the buzziest drug in the weight loss world. However, it isn’t the only GLP-1 drug people are using to lose weight fast. Before you try and get a prescription, there are a lot of things you need to know about the drug, including how it works and also how it compares to similar treatments on the market. Here are ten key differences between Ozempic and other GLP-1 meds for weight loss, according to triple-board-certified plastic surgeon Leo Lapuerta, MD, The Plastic Surgery Institute of Southeast Texas.

Ozempic Isn’t Even Approved for General Weight Loss

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While Ozempic is probably the most well-known GLP-1, it isn’t technically even approved for general weight loss. “It is for the control of Type 2 diabetes,” Dr. Lapuerta reveals.

Most Weight Loss Drugs Aren’t Approved for Weight Loss

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In fact, most drugs being used for weight loss weren’t even intended for that purpose. “Most of the GLP-1 drugs like Rybelsus, Victoza, Trulicity, and Byetta are intended for the treatment of Type 2 diabetes with beneficial side effects that include weight loss,” explains Dr. Lapuerta.

RELATED:20 Possible Ozempic Side Effects

Some GLP-1s Offer Heart and Kidney Benefits

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There are other benefits to taking weight loss drugs. “Ozempic, Victoza, and Trulicity all have benefits for the heart and kidneys in addition to control of Type 2 diabetes,” says Dr. Lapuerta.

One Weight Loss Drug Is Injected Daily, Most of Them Are Weekly

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Most of the GLP-1s, including Ozempic, require a weekly injection. However, “Victoza is unique because it is injected daily rather than weekly,” says Dr. Lapuerta.

One Is Available in Oral Format

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And not all of them require a needle. “Rybelsus is the only GLP-1 that is available in oral format as all the other options are by injection only,” says Dr. Lapuerta.

RELATED:What Happens to Your Body When You Stop Taking Ozempic

Some of Them Are Approved for Weight Loss and Weight Management

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Ironically, while the most well-known of the bunch isn’t even approved for weight loss, the majority of the others are. “Wegovy, Saxenda, and Mounjaro (Tirzepatide) are GLP-1 agonists intended for weight loss and weight management rather than the treatment of Type 2 diabetes,” says Lapuerta.

Some Are More Effective Than Others

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According to Dr. Lapuerta, results vary by brand. “Wegovy typically produces 2 to 3 times the percent weight loss as Saxenda,” he maintains.

Only One of Them Includes GIP

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Mounjaro (Tirzepatide) has an edge over the competition. “It is the first GLP-1 to also include GIP, glucose-dependent insulinotropic polypeptide (GIP), another gut hormone agonist that provides better longer-term control of blood sugar as indicated by better reductions in Hemoglobin A1C levels,” says Dr. Lapuerta.

RELATED:20 Things to Avoid While on Ozempic

Some Medications Have Two Names

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Don’t let names deceive you. “Zepbound is the FDA-approved version of Mounjaro specifically for weight loss,” says Dr. Lapuerta.

Keep Reading About Ozempic

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Keep educating yourself about Ozempic. Here are 15 things you should know before getting Ozempic for weight loss. And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.