Nutrition & Diet

9 Key Differences Between Ozempic and Other GLP-1 Meds for Weight Loss

Here is what you need to know about the trendiest weight loss drugs, according to an MD.

June 26, 2024

Valparaiso IN USA - March 21, 2024: Ozempic semaglutide injection pen and Rybelsus Semaglutide tablets close up — Shutterstock

Ozempic is the buzziest drug in the weight loss world. However, it isn't the only GLP-1 drug people are using to lose weight fast. Before you try and get a prescription, there are a lot of things you need to know about the drug, including how it works and also how it compares to similar treatments on the market. Here are ten key differences between Ozempic and other GLP-1 meds for weight loss, according to triple-board-certified plastic surgeon Leo Lapuerta, MD, The Plastic Surgery Institute of Southeast Texas.

Ozempic Isn't Even Approved for General Weight Loss

Montreal, CA - 16 November 2023: Ozempic semaglutide injection pens and box. Ozempic is a medication for obesity — Shutterstock

While Ozempic is probably the most well-known GLP-1, it isn't technically even approved for general weight loss. "It is for the control of Type 2 diabetes," Dr. Lapuerta reveals.

Most Weight Loss Drugs Aren't Approved for Weight Loss

Female bare feet with weight scale on wooden floor — Shutterstock

In fact, most drugs being used for weight loss weren't even intended for that purpose. "Most of the GLP-1 drugs like Rybelsus, Victoza, Trulicity, and Byetta are intended for the treatment of Type 2 diabetes with beneficial side effects that include weight loss," explains Dr. Lapuerta.

Some GLP-1s Offer Heart and Kidney Benefits

High resolution man drawing chart heartbeat — Shutterstock

There are other benefits to taking weight loss drugs. "Ozempic, Victoza, and Trulicity all have benefits for the heart and kidneys in addition to control of Type 2 diabetes," says Dr. Lapuerta.

One Weight Loss Drug Is Injected Daily, Most of Them Are Weekly

Victoza Insulin group emerging from a medication for diabetes patients. studio shot on a white background in Viktoza box. Diabetes drugs. — Shutterstock

Most of the GLP-1s, including Ozempic, require a weekly injection. However, "Victoza is unique because it is injected daily rather than weekly," says Dr. Lapuerta.

One Is Available in Oral Format

Ozempic semaglutide injection pen and Rybelsus Semaglutide tablets close up — Shutterstock

And not all of them require a needle. "Rybelsus is the only GLP-1 that is available in oral format as all the other options are by injection only," says Dr. Lapuerta.

Some of Them Are Approved for Weight Loss and Weight Management

Full length of excited Indian woman sitting on scales at home, overjoyed with success of her slimming diet, side view. Emotional Asian lady achieving her weight loss goal, making YES gesture — Shutterstock

Ironically, while the most well-known of the bunch isn't even approved for weight loss, the majority of the others are. "Wegovy, Saxenda, and Mounjaro (Tirzepatide) are GLP-1 agonists intended for weight loss and weight management rather than the treatment of Type 2 diabetes," says Lapuerta.

Some Are More Effective Than Others

Valparaiso, IN USA - January 22, 2024: Wegovy semaglutide pens for treatment of chronic obesity, close up — Shutterstock

According to Dr. Lapuerta, results vary by brand. "Wegovy typically produces 2 to 3 times the percent weight loss as Saxenda," he maintains.

Only One of Them Includes GIP

Basrah, Iraq - November 24, 2023: photo of Mounjaro Weight Loss Pen in hand — Shutterstock

Mounjaro (Tirzepatide) has an edge over the competition. "It is the first GLP-1 to also include GIP, glucose-dependent insulinotropic polypeptide (GIP), another gut hormone agonist that provides better longer-term control of blood sugar as indicated by better reductions in Hemoglobin A1C levels," says Dr. Lapuerta.