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10 Long-Term Possible Side Effects of Ozempic

Here’s what you need to know before taking the drug.

FACT CHECKED BY Christopher Roback
An elderly woman is sitting on the sofa at home, holding her stomach with her hands. Feels the pain of internal organs, indigestion, poisoning, menstrual pain.
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FACT CHECKED BY Christopher Roback

Ozempic is the most well-known semaglutide medication being used right now, thanks to many celebrities openly (and not so openly!) using the drug for weight loss. Although Ozempic is highly effective as a weight loss drug, technically, it’s meant to be used as a type 2 diabetes medication, which is what it was created for. Although it’s only recently that the drug has been trending, Ozempic was approved by the FDA in 201—so we have at least seven years of data to go on when it comes to side effects. Here are ten possible long-term side effects of using Ozempic, according to studies and official company information.


Inflammation of the Pancreas

Chronic back pain. Adult woman is holding her lower back, while standing and suffering from unbearable pain.Shutterstock

Ozempic can cause pancreatitis, according to the official warning label: “Stop using Ozempic and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.”

Changes in Vision

Professional optometrist holding glasses and eye chart in the background, eyesight and vision problems concept, copy spaceShutterstock

Ozempic can cause vision issues. “It may seem strange that a drug made to help control diabetes could make your eyesight worse, but it’s something we’ve known about for a while,” says Raj K Maturi, MD. “A large clinical study suggested an association between blood sugar control and worsening of diabetic retinopathy.”

RELATED: 20 Incredible Ozempic Success Stories of All Time

Low Blood Sugar

Blured photo of a woman suffering from vertigo or dizziness or other health problem of brain or inner ear.Shutterstock

Ozempic can cause hypoglycemia in some people. “Signs and symptoms of low blood sugar may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery,” Ozempic makers warn.

Kidney Problems

, mature,Middle,Age,Man,Drinking,Glass,Of,Water,Sitting,On,SofaShutterstock

Ozempic can cause kidney problems and kidney failure. “In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse,” Ozempic makers warn. “It is important for you to drink fluids to help reduce your chance of dehydration.”

However, research shows taking Ozempic actually shows benefits for kidney disease. “We are ecstatic that we are seeing real benefits for people with chronic kidney disease,” Katherine Tuttle, a nephrologist at the University of Washington School of Medicine in Spokane who co-ran the trial, tells Nature. “These patients benefit broadly.”

Serious Allergic Reactions

Portrait Of A Young Woman Suffering From Chest PainShutterstock

Some people may have an allergic reaction to Ozempic, and should stop taking it immediately. “Get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat,” the makers warn.

RELATED: 20 Things You Need to Know About Ozempic and Weight Loss

Gallbladder Problems

Serious Caucasian male doctor in white medical uniform talk discuss results or symptoms with female patient, man GP or physician consult woman client give recommendation at meeting in hospitalShutterstock

Some people who take Ozempic experience gallbladder issues. “Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes,” according to research published in the Journal of the American Medical Association.

Nausea and Vomiting

Ill man sitting on his bed with his head on his handShutterstock

Some people on higher doses of Ozempic experience nausea and vomiting. The makers have advice to lessen the symptoms:

  • Eat bland, low-fat foods, like crackers, toast, and rice
  • Eat foods that contain water, like soups and gelatin
  • Avoid fried, greasy, or sweet foods
  • Avoid lying down after you eat
  • Go outdoors for fresh air
  • Eat more slowly
  • Drink clear or ice-cold drinks

Stomach Pain

An elderly woman is sitting on the sofa at home, holding her stomach with her hands. Feels the pain of internal organs, indigestion, poisoning, menstrual pain.Shutterstock

Some people using Ozempic experience stomach pain. “Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes,” researcher Mohit Sodhi tells NBC News.

RELATED:What Happens to Your Body When You Stop Taking Ozempic

Constipation and Diarrhea

Symbol of a public toiletShutterstock

Constipation and diarrhea are common side effects of Ozempic. “Gradual dosing while on Ozempic is crucial to mitigate the risk of severe constipation associated with higher doses,” Andrew Le, MD, tells Buoy Health. “Constipation caused by Ozempic usually subsides over time, with the median duration of constipation lasting 47 days.”

Thyroid Tumors

Terrible pain in his throat. Frustrated handsome young man touching his neck and holding a glass of water while sitting on the couch at homeShutterstock

One possible side effect of Ozempic is thyroid cancer. The makers of Ozempic warn, “Tell your health care provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.”

However, one of the biggest studies to explore the link between Ozempic and thyroid cancer found no substantial increased risk. “Our study covers a broad group of patients and provides strong support that GLP-1 analogs are not associated with an increased risk of thyroid cancer,” Björn Pasternak, principal researcher at the Department of Medicine at Karolinska Institutet, said in a statement.

💪🔥Body Booster: Talk to your doctor about the risk/reward of taking a semaglutide medication.

More For You

An elderly woman is sitting on the sofa at home, holding her stomach with her hands. Feels the pain of internal organs, indigestion, poisoning, menstrual pain.
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FACT CHECKED BY Christopher Roback
Fact-Checked

Our content is fact checked by our senior editorial staff to reflect accuracy and ensure our readers get sound information and advice to make the smartest, healthiest choices.

We adhere to structured guidelines for sourcing information and linking to other resources, including scientific studies and medical journals.

If you have any concerns about the accuracy of our content, please reach out to our editors by e-mailing editors@bodynetwork.com.

Ozempic is the most well-known semaglutide medication being used right now, thanks to many celebrities openly (and not so openly!) using the drug for weight loss. Although Ozempic is highly effective as a weight loss drug, technically, it’s meant to be used as a type 2 diabetes medication, which is what it was created for. Although it’s only recently that the drug has been trending, Ozempic was approved by the FDA in 201—so we have at least seven years of data to go on when it comes to side effects. Here are ten possible long-term side effects of using Ozempic, according to studies and official company information.


Inflammation of the Pancreas

Chronic back pain. Adult woman is holding her lower back, while standing and suffering from unbearable pain.Shutterstock

Ozempic can cause pancreatitis, according to the official warning label: “Stop using Ozempic and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.”

Changes in Vision

Professional optometrist holding glasses and eye chart in the background, eyesight and vision problems concept, copy spaceShutterstock

Ozempic can cause vision issues. “It may seem strange that a drug made to help control diabetes could make your eyesight worse, but it’s something we’ve known about for a while,” says Raj K Maturi, MD. “A large clinical study suggested an association between blood sugar control and worsening of diabetic retinopathy.”

RELATED: 20 Incredible Ozempic Success Stories of All Time

Low Blood Sugar

Blured photo of a woman suffering from vertigo or dizziness or other health problem of brain or inner ear.Shutterstock

Ozempic can cause hypoglycemia in some people. “Signs and symptoms of low blood sugar may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery,” Ozempic makers warn.

Kidney Problems

, mature,Middle,Age,Man,Drinking,Glass,Of,Water,Sitting,On,SofaShutterstock

Ozempic can cause kidney problems and kidney failure. “In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse,” Ozempic makers warn. “It is important for you to drink fluids to help reduce your chance of dehydration.”

However, research shows taking Ozempic actually shows benefits for kidney disease. “We are ecstatic that we are seeing real benefits for people with chronic kidney disease,” Katherine Tuttle, a nephrologist at the University of Washington School of Medicine in Spokane who co-ran the trial, tells Nature. “These patients benefit broadly.”

Serious Allergic Reactions

Portrait Of A Young Woman Suffering From Chest PainShutterstock

Some people may have an allergic reaction to Ozempic, and should stop taking it immediately. “Get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat,” the makers warn.

RELATED: 20 Things You Need to Know About Ozempic and Weight Loss

Gallbladder Problems

Serious Caucasian male doctor in white medical uniform talk discuss results or symptoms with female patient, man GP or physician consult woman client give recommendation at meeting in hospitalShutterstock

Some people who take Ozempic experience gallbladder issues. “Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes,” according to research published in the Journal of the American Medical Association.

Nausea and Vomiting

Ill man sitting on his bed with his head on his handShutterstock

Some people on higher doses of Ozempic experience nausea and vomiting. The makers have advice to lessen the symptoms:

  • Eat bland, low-fat foods, like crackers, toast, and rice
  • Eat foods that contain water, like soups and gelatin
  • Avoid fried, greasy, or sweet foods
  • Avoid lying down after you eat
  • Go outdoors for fresh air
  • Eat more slowly
  • Drink clear or ice-cold drinks

Stomach Pain

An elderly woman is sitting on the sofa at home, holding her stomach with her hands. Feels the pain of internal organs, indigestion, poisoning, menstrual pain.Shutterstock

Some people using Ozempic experience stomach pain. “Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes,” researcher Mohit Sodhi tells NBC News.

RELATED:What Happens to Your Body When You Stop Taking Ozempic

Constipation and Diarrhea

Symbol of a public toiletShutterstock

Constipation and diarrhea are common side effects of Ozempic. “Gradual dosing while on Ozempic is crucial to mitigate the risk of severe constipation associated with higher doses,” Andrew Le, MD, tells Buoy Health. “Constipation caused by Ozempic usually subsides over time, with the median duration of constipation lasting 47 days.”

Thyroid Tumors

Terrible pain in his throat. Frustrated handsome young man touching his neck and holding a glass of water while sitting on the couch at homeShutterstock

One possible side effect of Ozempic is thyroid cancer. The makers of Ozempic warn, “Tell your health care provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.”

However, one of the biggest studies to explore the link between Ozempic and thyroid cancer found no substantial increased risk. “Our study covers a broad group of patients and provides strong support that GLP-1 analogs are not associated with an increased risk of thyroid cancer,” Björn Pasternak, principal researcher at the Department of Medicine at Karolinska Institutet, said in a statement.

💪🔥Body Booster: Talk to your doctor about the risk/reward of taking a semaglutide medication.

FACT CHECKED BY Christopher Roback
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Are you considering using Ozempic or another similar weight loss drug to help you achieve your goals? Health Coach Kaitlin Malthaner has a BSc in Nutrition and Exercise and is a certified health and nutrition coach specializing in blood sugar control and insulin resistance. In one of her viral YouTube videos, she explains everything you should know about Ozempic. “It's important to know the facts before you start Ozempic because while it is certainly an effective drug for weight loss, there are side effects and risks. And for a drug that's only been around since 2012, there's still a lot we don't know,” she says.


Here Is What Ozempic Is

Montreal, CA - 16 November 2023: Ozempic semaglutide injection pens. Ozempic is a medication for obesityShutterstock

“Ozempic is the brand name for the prescription drug—semaglutide, which is created to treat type 2 diabetes. Semaglutide is meant to be injected once a week into subcutaneous fat, which is the squishy fat we carry around our body. Now, like I said, it was originally created to treat type 2 diabetes because it's effective in lowering blood sugar. And one of the positive side effects of lowering high blood sugar is weight loss,” she explains. “Because of this, a lot of people who find it difficult to lose weight are turning to ozempic.”

It Increases Insulin Released From the Pancreas and Decreases Glucagon

“Semaglutide, which is the active ingredient in ozempic, increases the amount of insulin your pancreas releases and decreases the release of glucagon,” she continues. “Insulin and glucagon are hormones that counter each other. When we eat, insulin is released to take the excess sugar from our meal to the cells in our body that need it. And when we haven't eaten for a while, glucagon is released to stop blood sugar from dropping too low. So generally, when insulin is high, glucagon is low, and when glucagon is high, insulin is low.”

RELATED:20 Possible Ozempic Side Effects

It Also Slows Down How Quickly Food Is Processed and Affects the Hunger Center of the Brain

GDANSK, POLAND - MAY 2022: obese fat man preparing Semaglutide Ozempic injection control blood sugar levelsShutterstock

Semaglutide also slows down how quickly food is processed, she explains. “So any spikes in blood sugar are more gradual.” It also affects the hunger center in the brain, “reducing cravings and hunger in general,” she says. So, how does this play in with weight loss? “The main reason that it's so effective is because of the decrease in hunger and appetite; if it just increased insulin without doing anything else, this would only cause insulin resistance. And that's the other part of this. Most people who are prescribed this drug are already insulin resistant, and that is what is stopping them from losing weight.”

Side Effect 1: Muscle Loss

Bearded thin man measuring biceps, muscles of his left arm with a yellow tape measure. He's calm, serious, quiet. Wearing blue t-shirt. White background.Shutterstock

However, there are some “not-so-pleasant side effects that you should be aware of because, unfortunately, it isn't a miracle drug,” she says. “The first one is muscle loss. So yes, ozempic is very effective for weight loss. And I say weight loss here because not all of the weight you lose is going to be from fat. In fact, Ozempic weight loss is often an equal mix of muscle and fat. This can actually leave you with a higher percentage of body fat relative to your muscles. And you might be thinking, okay, I don't care. As long as the scale is going down, that's all that matters. But losing muscle mass is not something to take lightly, especially as we age. We want to retain as much as we can in order to maintain good health. Muscle loss accelerates as we age, and by our later years, muscle mass becomes a crucial indicator of longevity. People with less muscle mass tend to live shorter lives, and there is a very strong correlation here,” she says. “Either way, if you do decide to go the ozempic route, it is so important to make sure that you're eating enough protein. This is going to help you hold onto your muscle mass. And like I said, this is even more important when you're taking Oozempic.”

RELATED:20 Things to Avoid While on Ozempic

Side Effect 2: Ozempic Face and Accelerated Aging

Tired woman looking her eye bags in the bathroom.Shutterstock

Number two is accelerated aging, “and this becomes particularly noticeable in the face,” she says. “Ozempic can lead to a loss in facial fat specifically, which unfortunately can cause your skin to sag. And dermatologists have become pretty good at spotting this.” This is why many people end up needing filler and Botox. “So yes, while you may be shedding weight rapidly, it's important to note that you might lose some from your face. And this can make you look older than you are again. There's going to be a trade-off to consider here.”

Side Effect 3: Kidney Disease

Young woman touching her kidney in pain.Shutterstock

Number three is kidney disease. “So now we're getting into some of the more serious side effects, although I would argue that muscle loss is pretty serious, the potential impact that Ozempic can have on your kidneys, even more so, there have been reports of ozempic causing new cases of kidney disease, worsening existing kidney conditions, and even leading to kidney failure in some individuals. So if you already have kidney issues, this is definitely something to consider or even if they run in your family,” she says.

RELATED:I Hit 60 and These 15 Anti-Aging Foods Keep Me Fit and Feeling 20 Years Younger

Side Effect 4: Blurry Vision

Blured photo of a woman suffering from vertigo or dizziness or other health problem of brain or inner ear.Shutterstock

Number four: blurred vision. “This is another side effect of ozempic that is actually pretty common. It's well documented, but it's not often talked about. And this can start even as soon as a few weeks after you start taking the medication. Some people who experience this find that their vision becomes so impaired they can no longer read signs or drive safely at night. Now, it's important to note that not everyone will experience this side effect, but it is important to know that for some people who do experience it, even when they stop taking ozempic, their vision does not return to how it was prior” she says.

Side Effect 5: Thyroid Cancer

Doctor talking to patient in officeShutterstock

And finally, the fifth side effect to be aware of is thyroid cancer, “and this is one of the most concerning potential side effects,” she says. “Warnings about the risk of thyroid tumors and thyroid cancer are clearly listed on ozempic packaging, and these concerns stem from studies that have shown the drug causes cancer in animals. Now, it's important to note that we don't yet know how this translates to humans. As I mentioned at the start of this video, Ozempic Semaglutide has only been around since 2012, so we haven't been using it long enough for these side effects to play out fully in humans. However, if you have thyroid issues, this is definitely something you want to consider.”

RELATED:I Lost 32 Pounds of Fat and Inches Off My Waist With This Method

There Are Also Natural Ways to Stabilize Your Blood Sugar

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“The reason that ozempic is so effective is because it helps to control your appetite and ultimately helps to stabilize your blood sugar. And the good news here is that there are natural ways to mimic this without these side effects. By making a few small diet and lifestyle changes like starting your day with a high protein and high-fat breakfast, taking walks after your meals, and supplementing berberine, you can balance your blood sugar and make weight loss easier,” she reveals.

She Recommends Trying Berberine

“Berberine is a supplement that is extremely effective,” she says. “It's a natural compound that has been extensively studied and proven to lower blood sugar and improve insulin sensitivity, which can be a game changer for your health and your weight loss efforts,” she continues.”Like I said, it's been heavily researched and shown to be extremely effective, so it's worth giving it a try.” And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.

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FACT CHECKED BY Christopher Roback
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Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

Type 2 diabetes drug Ozempic is clearly very effective as a weight-loss tool—but it may not work for everyone. As people respond differently to different drugs, side effects that barely register for one person may seem debilitating for another. Is it worth it? Some experts say the weight loss results are beneficial far beyond mere superficial reasons. "By treating obesity, you’re effectively potentially treating over 200 other obesity-related or weight-related diseases," Dr. Ania Jastreboff, an associate professor of medicine at the Yale School of Medicine who serves on the scientific advisory board of Novo Nordisk, tells NBC News.


“Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes,” researcher Mohit Sodhi tells NBC News. If the negative side effects outweigh the efficacy of the medication, it might not seem worth it. Here are 11 signs Ozempic may not be for you.

Vision Problems

Close up portrait of an attractive man with eyeglasses. Poor young guy has eyesight problems. He is rubbing his nose and eyes because of wearinessShutterstock

Ozempic may negatively impact your eyesight. “It may seem strange that a drug made to help control diabetes could make your eyesight worse, but it’s something we’ve known about for a while,” saysRaj K Maturi, MD. “A large clinical study suggested that there is an association between blood sugar control and worsening of diabetic retinopathy.”

Ozempic Face

Sad,Wealthy,Woman,Suffering,From,Depression,Hiding,Her,Face,MoneyShutterstock

“Ozempic face” is the term used to describe the effect of quick fat loss on facial appearance. “You may have heard about "Ozempic face" as a side effect of GLP-1 drugs, though the term is misleading because this can be a side effect of any GLP-1 drug or any other cause of rapid weight loss,” says Harvard Health. “If weight is lost in a more gradual way, these changes may not be as noticeable. It's the faster pace of weight loss that occurs with GLP-1 drugs that can make facial changes more obvious.”

Vomiting and Nausea

Young woman sitting on the bed with hard stomach pain.Shutterstock

Nausea and vomiting are among the more debilitating side effects of taking Ozempic. “Nausea can be managed by avoiding strong smells and eating crackers, mint, or ginger-based food or drinks about a half hour after taking a GLP-1 drug,” says Harvard Health. “Vomiting can be managed by staying well hydrated and having more frequent meals in smaller amounts.”

Gallbladder Warning

Woman with abdominal pain in the middle above the navel. She sits on the sofa at home.Shutterstock

In some rare cases, taking drugs such as Ozempic may cause gallbladder issues. “Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes,” according to research published in the Journal of the American Medical Association.

Low Blood Sugar

Dizzy Woman With Balance Loss. Vertigo DisorderShutterstock

Taking Ozempic may cause hypoglycemia, which comes with its side effects. “Signs and symptoms of low blood sugar may include dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery” Ozempic makers warn.

GI Issues

Closeup hand pulling toilet paper roll in holder for wipe, woman sitting on toilet she taking and tearing white tissue on wall to towel clean in bathroom, Healthcare conceptShutterstock

Some people experience unpleasant GI issues such as diarrhea and constipation. “Diarrhea can be managed by drinking plenty of water and avoiding dairy products and high-fiber foods until symptoms go away,” says Harvard Health. “Constipation can be managed by getting enough fiber in your diet and drinking plenty of water.”

RELATED: The Healthiest and Unhealthiest Ways to Cook Your Eggs

Pancreatitis

Mature woman doctor talk with patient about diagnose at doctors officeShutterstock

Ozempic is linked to pancreatitis, so people at risk of the condition should be wary. “We generally do not use this class of medicines if someone has a history of pancreatitis,” Dr. Cecilia Low Wang tells UCHealth.

Kidney Issues

Young woman touching her kidney in pain.Shutterstock

“In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse,” Ozempic makers warn. “It is important for you to drink fluids to help reduce your chance of dehydration.”

Adjust Your Dose

Santiago, Chile, august 16th, 2023. Pen injection of semaglutide named “ozempic”, is a diabetes medicine to improve blood sugarShutterstock

Sometimes, the dose itself might be the problem. “About one in five people might stop because they are experiencing bad side effects,” Dr. Low Wang says. “I encourage some patients to stay at the lower dose level for a longer period of time to see if they can tolerate it better and still get some benefit from the medication. Or if they don’t tolerate this medication, we might try a different one.”

Address the Issue

GDANSK, POLAND - MAY 2022: obese fat man preparing Semaglutide Ozempic injection control blood sugar levelsShutterstock

Taking Ozempic without addressing the cause of weight gain may undermine long-term weight loss. “There are lots of emotional and behavioral factors that contribute to health and eating patterns. Suppose you're not addressing those issues while taking a medication that's designed to help weight loss. In that case, you're really going to compromise the overall effectiveness of the medicine,” says Joseph Trunzo, PhD, Psychology professor and associate director of Bryant’s School of Health and Behavioral Sciences.

RELATED: 7 Things to Do When You Wake Up to Melt Fat

Weight Loss Plateau

Legs of men standing on scales weight. Concept of health and weight loss.Shutterstock

If you stop taking Ozempic, your weight may pile back on. “It’s important to note that if you start taking either of these drugs for weight loss, your body may get used to it, establishing a new normal,” says UC Davis Health. “This can cause your weight to plateau. Research has shown that if you stop taking Ozempic (or Wegovy), it's likely that you will gain back the weight you lost.” And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.

Portrait of stressed young housewife in modern kitchen
Shutterstock
FACT CHECKED BY Christopher Roback
Fact-Checked

Our content is fact checked by our senior editorial staff to reflect accuracy and ensure our readers get sound information and advice to make the smartest, healthiest choices.

We adhere to structured guidelines for sourcing information and linking to other resources, including scientific studies and medical journals.

If you have any concerns about the accuracy of our content, please reach out to our editors by e-mailing editors@bodynetwork.com.

Most people are so focused on what happens while they are taking Ozempic – ranging from the pros of weight loss to the cons of some of the most common side effects – that they tend to ignore what happens after you stop getting the jab. There are actually lots of ways your body can react post-Ozempic, according to Kylie Bensley, MS, RD, Certified Nutritionist, Clinical Dietician, and Founder of Sulinu. Here are key things that could happen.


Your Blood Sugar Could Spike

Measuring blood sugar with a blood glucose meterShutterstock

According to Bensley, if people with diabetes stop taking it, their blood sugar returns to normal pre-Ozempic levels. “43 percent of people with prediabetes were able to keep their blood sugar within normal limits after stopping Ozempic,” she says. This can lead to worsening side effects of elevated blood glucose that can negatively impact heart, eye, and nerve health.

You Might Get a Fungal/Yeast Infection

Medicine,,Healthcare,And,People,Concept,-,Female,Doctor,With,TabletShutterstock

Bensley also maintains that due to your blood sugar spiking, you will be more susceptible to fungal/yeast infections. “Revisit trialing diabetes medications or begin natural supplementation of blood sugar regulation, such as Berberine,” she recommends. Also, walking for 10 minutes after meals has been shown to keep blood sugar stable.

Your Mood Could Change

Unpleasant,Pain.,Sad,Unhappy,Man,Sitting,On,The,Sofa,depressedShutterstock

Mood changes due to more erratic blood sugar are also possible. “Higher blood sugar has been associated with anger and sadness. Lower blood sugar has been associated with nervousness, confusion, irritability, difficulties with concentration and decision making,” she says. In addition to her previous suggestion, she recommends carb pairing, “making sure that carbs always have friends and they are never consumed alone,” she says. “This slows the transit of the blood sugar in the system and prevents erratic spikes.”

A Plus? Side Effects Subside

An elderly woman is sitting on the sofa at home, holding her stomach with her hands. Feels the pain of internal organs, indigestion, poisoning, menstrual pain.Shutterstock

On a positive note, side effects of Ozempic subside when you stop getting the jab. “Many people have GI distress symptoms such as nausea and vomiting that subside when stopping the medication,” says Bensley. “You may also be able to stop your anti-nausea medication and your laxative at the same time you stop Ozempic.”

You Probably Won’t Experience Any Changes for a Week

Woman,,Balance,Weight,Scale,health,scalesShutterstock

Don’t expect changes for a week after you get your last jab due to Ozempic’s half-life. “Ozempic’s half-life is a week; this means that within a week, half of the medication has left your system,” says Bensley. “It completely leaves your system in 4-5 weeks,” she adds. A bonus? Even though you stop, you may still be seeing weight loss for up to a month.

Your Appetite Will Probably Increase

Rear View Of A Confused Woman Looking In Open Refrigerator At HomeShutterstock

Appetite can begin increasing after a week after Ozempic. “As you eat more, increase your exercise (even if it’s just walking),” Bensley recommends. “Sulinu’s Ozempic Protocol (launching this summer), created by surgeons and dietitians, will help clients navigate how to deal with hunger cues once their hunger returns.”

Food Noise Might Return

Hungry man opens the refrigerator at nightShutterstock

Expect food noise to return. “With the withdrawal of a hunger-suppressing medication, the well-known ‘Food Noise’ returns with thoughts on ‘What do I eat now that I am hungry again?’ At Sulinu, we are creating an Ozempic Protocol to help patients understand how to deal with food noise without gaining weight. It is so important to understand and listen to hunger cues and be prepared for what you will eat when you feel hungry.”

RELATED:5 Foods That Maximize Weight Loss on GLP-1 Medicines, According to Coach

You Might Experience Withdrawal Effects, Like Dizziness

Blured photo of a woman suffering from vertigo or dizziness or other health problem of brain or inner ear.Shutterstock

Withdrawal effects, including dizziness, are also possible. This is associated with adverse cardiovascular changes, explains Bensley. “Make sure you discuss this with your healthcare provider.”

Headaches Are Also Possible

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Another withdrawal effect? Headaches, Bensley says, are also associated with adverse cardiovascular changes. “It is important to have a visit to your PCP as these headaches could be related to rising blood pressure.”

Another Positive? Your Cholesterol Will Continue Improving

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Your cholesterol still improves even after Ozempic, says Bensley. “Even after stopping Ozempic, studies still showed improvement in people’s cholesterol levels,” she reveals.

Your Blood Pressure Will Likely Change

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You might experience blood pressure changes. “Most people’s blood pressure returned to their pre-Ozempic levels when stopping the medication,” she says. “With heart health labs quickly changing, many side effects can follow such as headaches, chest pain, dizziness, difficulty breathing, nausea, vomiting, nosebleeds, abnormal heartbeat, vision changes, anxiety, confusion and buzzing in the ears,” she continues. “Create a plan with your PCP on how you will monitor your BP. High blood pressure is to be taken very seriously- it takes more than 500,000 lives a year in the US.”

You Might Gain Weight in Certain Area

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“Weight gain around the central region, which surrounds the key organs where we develop fatty liver disease,” is also common. “One year after stopping Ozempic, a study showed people gained back an average of ⅔ of what they lost on Ozempic,” says Bensley.

RELATED: 20 Things You Need to Know About Ozempic and Weight Loss

However, You Might Retain Your Weight Loss

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However, Bensley adds that most people retain 5 percent weight loss. “The people who lost the most on Ozempic gained the most weight back but still had a higher net loss that remained after 1 year,” she explains. Another study showed that an average person lost 10 percent of their weight taking Ozempic and had gained back an average of 7 percent after one year.” She recommends exercising to mitigate weight gain. “Some studies show that high-intensity exercise can slow the progression of fatty liver disease,” she explains.

Your Pocketbook Will Get Fatter

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Your pocketbook will get fatter when you stop Ozempic. “Without insurance, Ozempic can run nearly $1,000/per month, so stopping the medication has significant financial advantages,” Bensley points out.

Fear of Weight Gain Could Sink In

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You will likely become afraid of gaining weight. “This fear is one of the most talked about and one of the most common questions I get. In fact, it keeps women from even getting on the medication in the first place as they are so afraid the rebound weight gain will be worse than their original weight,” says Bensley. “I am a huge believer in taking the Ozempic with a medical professional such as a nurse practitioner or physician. A Registered Dietitian can help tremendously here as well. They will help you create a game plan for success.”

You Might Get Diarrhea

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You might also experience gastrointestinal issues, like diarrhea. “The exact reason is not clear, but it may be due to how Ozempic affects gut transit,” she says.

RELATED:20 Things to Avoid While on Ozempic

CRP Improvements

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CRP improvements (inflammation marker) could also happen. “CRP remained improved even after stopping Ozempic. This shows that inflammation is still improving!” she says.

Ozempic Is Actually Only Approved for Those with Type 2 Diabetes

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Keep in mind that Ozempic isn’t a weight loss drug. According to the National Library of Medicine it is approved to control blood sugar levels in adults with type 2 diabetes when other medications do not control the sugar levels well enough.

Wegovy Is Approved for Weight Loss

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“Semaglutide injection (Wegovy) is used to reduce the risk of a stroke, heart attack, or death in adults who are overweight or obese along with heart and blood vessel disease,” they say, adding that “used along with an individualized low-calorie, low-fat diet and exercise program” it can help with weight loss “in obese adults or overweight adults who may also have high blood pressure, diabetes, or high cholesterol” and in obese children 12 years of age or older.

RELATED: How I Lost 30 Pounds in 90 Days on the Mediterranean Diet

Most Common Side Effects

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These are the most common side effects of Ozempic and Wegovy:

  • nausea
  • vomiting
  • diarrhea
  • abdominal pain
  • constipation
  • heartburn
  • burping.

And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.

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FACT CHECKED BY Christopher Roback
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With 1 in 8 US adults having tried a GLP-1 drug like Ozempic or Mounjaro at some point and half of those currently using a prescription, approximately 15 million people are taking these drugs, according to a survey by KFF. With the popularity of these medications exploding, tracking side effects is more important than ever. New research published in JAMA shows that non-diabetics who take the drugs could experience serious and unpleasant side effects. Here’s what those side effects are, plus others to expect from taking a GLP-1 drug.


Pancreatitis

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Non-diabetic users have a roughly nine times higher chance of developing pancreatitis. “It's definitely important that we're talking about this, but I want to keep it in perspective,” Dr. Tara Narula tells TODAY. “These drugs have been around and treating diabetic patients for over ten years, and we've really known about a lot of these side effects, bowel obstruction, pancreatitis, in fact, many of them are on the labels for these drugs.”

Bowel Obstruction

Non-diabetic users have a four times higher risk of a bowel obstruction. “But the absolute risks are small, so these are rare,” Dr. Narula says. “We're talking about, for example, gastroparesis, which is this concept of slowing stomach emptying. We're talking about going from 0.3% with these non-GLP drugs to 1% with Ozempic, 0.3% to 0.8 or 0.7% with the other drugs. So these are small increases.”

RELATED:What Happens to Your Body When You Stop Taking Ozempic

Stomach Paralysis

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Non-diabetic users have a more than three-and-a-half times higher risk of stomach paralysis. “That's actually how this drug partially works, which is slowing the emptying of the stomach,” Dr. Narula says. “So it helps you feel fuller longer. The problem is, in some people, if it is severe, you will end up with nausea, vomiting, abdominal pain, feeling full bloating. So it's important we're raising awareness, but we want to keep it in perspective.”

No Off-Label Drugs

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Dr. Narula makes it clear no one should be trying to get these drugs without going through a medical professional. “People should not be getting this drug off the internet,” she says. “They should not be getting it without sitting down with a healthcare provider who can really talk to you about the risks and the benefits. Are you someone, for example, who has a history of bowel problems or pancreatitis? Then you probably shouldn't be taking this drug. Do the benefits outweigh? And yes, for obesity, we're talking about cardiovascular risks, cancer risks.”

Take It Slow

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Dr. Narula recommends starting on a low dose and increasing if necessary. “For a lot of people, there is going to be a benefit here, but you really want to do it the right way in terms of starting these drugs. Start low; you don't increase it until four to six weeks. You monitor for side effects, and if you need to, you can lower the dose. This healthcare provider should be talking to you about non-GI risks as well.”

There Are Benefits Too

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Dr. Narula says 40 to 60% of my patients are talking about GLP-1 drugs. “I mean, so many of my patients struggle with obesity, and many of them want to know about other options besides bariatric surgery and meeting with a nutritionist,” she says. “They say I've tried everything, and I can't figure out a way to lose weight. And we know that with these medications, we are seeing benefits in a cardiovascular high-risk population for lowering the risk of heart attack and stroke. So there are benefits for those people. So it is important to talk to your doctor about it. It's not for everyone. It may be for you, but really have that conversation.”

RELATED: 20 Things You Need to Know About Ozempic and Weight Loss

Vision Issues

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Ozempic and Wegovy may also cause several other side effects, like vision issues. “It may seem strange that a drug made to help control diabetes could make your eyesight worse, but it’s something we’ve known about for a while,” says Raj K Maturi, MD. “A large clinical study suggested that there is an association between blood sugar control and worsening of diabetic retinopathy.”

Hypoglycemia

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Ozempic may cause hypoglycemia in some people. “Signs and symptoms of low blood sugar may include dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery” Ozempic makers warn.

Gallbladder Issues

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Some people taking GLP-1 drugs may experience gallbladder issues. “Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes,” according to research published in the Journal of the American Medical Association.

Thyroid Cancer

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Ozempic may cause thyroid cancer, but a study shows no significant risk. “Our study covers a broad group of patients and provides strong support that GLP-1 analogs are not associated with an increased risk of thyroid cancer,” Björn Pasternak, principal researcher at the Department of Medicine at Karolinska Institutet, said in a statement.

RELATED:20 Possible Ozempic Side Effects

Ozempic Face

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Fast weight loss may lead to a more hollowed-out look to the face, hence the term ‘Ozempic Face’. “The term is misleading because this can be a side effect of any GLP-1 drug or any other cause of rapid weight loss,” Lisa Catanese, ELS, says via Harvard Health. “If weight is lost in a more gradual way, these changes may not be as noticeable. It's the faster pace of weight loss that occurs with GLP-1 drugs that can make facial changes more obvious.”

GI Issues

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GLP-1 drugs may cause constipation and diarrhea. “Gradual dosing while on Ozempic is crucial to mitigate the risk of severe constipation associated with higher doses,” Andrew Le, MD, tells Buoy Health. “Constipation caused by Ozempic usually subsides over time, with the median duration of constipation lasting 47 days.”

Fatigue and Headache

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Fatigue and headaches are also common side effects. “Gastrointestinal problems are the most common side effects since Wegovy can slow down people’s digestive systems,” Dr. Cecilia Low Wang, endocrinology, diabetes and metabolism expert, tells UC Health. “During clinical trials, some participants experienced nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, bloating and gas.”

RELATED: I Lost 10 Pounds in 30 Days With Walking and Eating Real Food

Severe Side Effects

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Dr. Low Wang says side effects can be so severe some people stop taking the drug. “About one in five people might stop because they are experiencing bad side effects,” she tells UC Health. “I encourage some patients to stay at the lower dose level for a longer period of time to see if they can tolerate it better and still get some benefit from the medication. Or if they don’t tolerate this medication, we might try a different one.” And if you enjoyed this article, don't miss 20 Incredible Ozempic Success Stories of All Time.

Autumn Bates
I'm a Nutrition Pro: This 28-Day Walking Routine Burns More Fat Than Cardio
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Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

We've all been there – faithfully hitting our daily walks but not seeing the fat loss results we expected. According to Autumn Bates, a certified clinical nutritionist with a master's in nutrition and human performance, walking is one of the most powerful tools for fat burning – when done correctly. With over 600,000 YouTube subscribers turning to her for evidence-based wellness advice, Autumn frequently identifies common walking mistakes that prevent her clients from achieving their fat loss goals. Read on to discover how small adjustments to your walking routine could reignite your fat-burning potential and help you start seeing results again.

Mistake 1: Not Walking Enough

The first mistake is straightforward – you simply aren't walking enough, says Autumn. While step counters and Fitbits can expose you to EMF, they're useful tools for establishing your baseline activity level.

RELATED:12-3-30 Walking Method: 20 Proven Tips to Lose Weight Faster

Know Your Baseline

"Very minimum I recommend getting in 10,000 steps a day," Autumn advises. If you're currently only walking 1,000-2,000 steps daily, don't try to jump immediately to 10,000. Instead, Autumn suggests incrementally increasing your steps – perhaps starting with a 2,000-step goal and adding 500-2,000 more steps each week.

Challenge Yourself Weekly

For those already hitting 8,000-10,000 steps, Autumn encourages pushing toward 15,000 steps. "With walking, the more the better," she explains, noting that most people tend to walk less than they should rather than more. Unlike running, which can elevate cortisol levels when overdone, you generally can't walk too much.

Mistake 2: Not Spreading Your Steps Throughout the Day

Even if you're achieving your step goal, Autumn points out that getting all your walking done in a single session while remaining sedentary the rest of the day is counterproductive.

RELATED:Tone Sagging Arms in 2 Weeks With These 5 Exercises

The Sitting-Inflammation Connection

"The longer you sit, the more inflammation you're going to have," Autumn warns. "And as we know, inflammation is really tied with weight gain or at least inability to lose weight."

Mini Walking Breaks

The solution is simple: break up your walking into smaller sessions scattered throughout the day. Autumn recommends five or ten-minute walks as breaks during your workday. This approach helps combat the inflammatory effects of prolonged sitting that can sabotage your fat-burning efforts.

Mistake 3: Only Walking on a Treadmill

While treadmill walking is better than no walking at all, Autumn emphasizes that outdoor walking offers unique benefits you can't get indoors.

RELATED:I'm a Nutritionist and These are the Best Banana Recipes For Weight Loss

The Power of Negative Ions

"If you are capable and if the weather allows for it to go walk outside, especially if you live by a park or some type of outside natural environment, then this will actually expose you to something called negative ions," Autumn explains.

Cortisol Reduction

These negative ions have been shown to reduce serum cortisol levels – the stress hormone associated with weight gain, particularly around the belly. Autumn notes that studies show you need at least 15 minutes of outdoor exposure to receive these benefits.

Making Walking Work For You

By incorporating these adjustments into your walking routine, you'll be better positioned to break through plateaus and continue making progress toward your fat-burning goals. As Autumn frequently reminds her clients, walking isn't just about getting steps in – it's about how you integrate this powerful tool into your lifestyle for maximum fat-burning benefits.

RELATED:I Got My Best Body After 50 and Here’s How You Can, Too

Start Where You Are

Remember that any improvement to your current walking routine is progress. Autumn recommends focusing on consistency first, then gradually implementing these changes for sustainable fat loss results.

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​Prioritize Whole Foods
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Evidence-Based

This content references scientific studies and academic research, and is fact-checked to ensure accuracy.

Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest.

We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible.

Do you want to shape up fast? According to an expert, you need to focus on only five habits. Karen Trasatti is a fat loss coach for women over 40 who looks half her age at 61. In a new viral Instagram post, she gets honest about what it takes to lose weight fast. “To all the midlife women out there…If you want to lose 10 pounds in the next 6 weeks and finally feel comfortable in your own skin, you need to commit to these 5 habits,” she writes.

These Habits Will Help You Feel Stronger and Also Boost Energy

“Want to lose 10 pounds in the next 6 weeks? If you’re a midlife woman and ready to shed some weight, feel stronger, and boost your energy, these are the 5 habits I would commit to,” she continues in the post.

RELATED:I Got My Best Body After 50 and Here’s How You Can, Too

Strength Train

The first habit she suggests is lifting weights, specifically strength training three times per week. “Muscle is your metabolism’s best friend! Lifting weights helps you burn more calories, even at rest,” she says. According to the Mayo Clinic, strength and weight training help reduce body fat, preserve and increase lean muscle mass, and burn calories more efficiently. Strength training may also help you:

  • Develop strong bones
  • Manage your weight
  • Enhance your quality of life
  • Manage chronic conditions
  • Sharpen your thinking skills

Prioritize Protein

Next, prioritize protein. “Aim for at least 25-30g per meal to support muscle and keep you full longer,” she says. According to clinical trials, consuming more protein than the recommended dietary allowance not only reduces body weight (BW), but also enhances body composition by decreasing fat mass while preserving fat-free mass (FFM) in both low-calorie and standard-calorie diets.

RELATED:12-3-30 Walking Method: 20 Proven Tips to Lose Weight Faster

Walk Daily

She also recommends hitting 7,000-10,000 steps daily. “Walking is underrated for fat loss and overall health. Move your body as much as possible!” she writes. A 2018 study published in the journal Obesity found a link between walking 10,000 steps a day and weight loss and weight management. Other studies published by the Journal of American Medical Association (JAMA) in JAMA Neurology and in JAMA Internal Medicine also linked walking 10,000 steps a day to less dementia and less cardiovascular disease overall, with less heart disease, less heart failure, and fewer strokes.

Track Macros (Not Just Calories!)

Her next tip is tracking macros – not just calories. “Balancing protein, carbs, and fats is key for sustainable weight loss,” she writes.

RELATED:8 High-Protein Foods with Nearly Zero Calories That Melt Fat

Sleep

Finally, get seven to nine hours of sleep every night. “Poor sleep messes with hormones and cravings, making fat loss harder. Prioritize rest!” she says. What are the health benefits of sleep? According to the Sleep Foundation, getting enough z’s is a mood booster, promotes heart health, regulates blood sugar, improves mental function, restores your immune system, helps relieve stress, and aids in weight loss. And if you enjoyed this article, take advantage of these 15 Quick Ways to Lose Body Fat Percentage in a Week.

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Are you trying to lose weight and keep it off? Losing 50 pounds is a big goal, but with the proper habits, it’s achievable. Regarding nutrition, remember to take it slow and not do any fad diets or eliminate entire food groups. As for exercise, moving your body is key, not just focusing only on diet. As a weight loss coach, I recommend these seven habits to my clients when they want to lose a lot of weight and keep it off.

1. Track Your Food Intake

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Use a food journal or an app (like MyFitnessPal or LoseIt) to log everything you eat. People who keep track are the most successful in losing and keeping weight off. Keeping a record of what you eat is accountability but also when you see the calories it is awareness of how quickly they add up throughout the day. Focus on calorie intake and make sure you are also spreading those calories throughout the day.

RELATED:I Got My Best Body After 50 and Here’s How You Can, Too

2. Prioritize Protein and Fiber

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Protein helps with muscle retention and keeps you full longer. Fiber-rich foods (vegetables, fruits, whole grains) improve digestion, reduce cravings, and also keep you feeling full.

3. Stay Hydrated

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Drink at least 80-100 ounces of calorie-free fluids throughout the day. Water is best, but you can also drink decaf tea or add flavor to your water to help drink enough.

RELATED:I'm a Nutritionist and These are the Best Banana Recipes For Weight Loss

4. Strength Train & Move More

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Incorporate strength training two to four times per week to build muscle and boost metabolism. When you lose weight you will lose some muscle. Doing strength training will help to maintain that muscle mass. Walk 10,000+ steps a day as a general rule. Get your heart rate up for at least 20 minutes a day most days of the week.

5. Watch Portions & Eat Mindfully

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Use smaller plates. Eat slowly to recognize fullness cues. Avoid eating in front of screens or in the car to be more mindful.

6. Get Quality Sleep (7-9 Hours Nightly)

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Poor sleep increases hunger hormones and cravings for unhealthy foods. Set a bedtime routine and limit screen time before bed.

RELATED:Tone Sagging Arms in 2 Weeks With These 5 Exercises

7. Stay Consistent & Adjust as Needed

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When you lose weight, it does not come off every single day; sometimes, you might even gain a pound or two. Stay patient and know the weight will come off if the habits are there. Focus on long-term sustainability rather than quick fixes.

Tara Collingwood, MS, RDN, CSSD, LD/N, ACSM-CPT, also known as The Diet Diva, is Body Network’s Resident Registered Dietitian Nutritionist. She is a Board-Certified Sports Dietitian and co-author of Flat Belly Cookbook for Dummies.